Results 191 to 200 of about 18,546 (234)

Genomic and Expression Analysis of Canine Calcitonin Receptor-stimulating Peptides and Calcitonin/Calcitonin Gene-related Peptide*

The Journal of Biochemistry, 2008
Calcitonin receptor-stimulating peptides (CRSPs) are new members of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family identified in pigs, dogs and other domestic animals, and CRSP-1 is an active ligand for the CT receptor (CT-R). We recently sequenced porcine CRSP genes (Crsps) and found similarity with the CT/CGRP gene (Ct/Cgrp) in ...
Tsukasa, Osaki, Takeshi, Katafuchi, Naoto, Minamino   +2 more
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Action of Calcitonin Gene-Related Peptide at the Calcitonin Receptor of the T47D Cell Line

Hormone and Metabolic Research, 1987
Some effects of calcitonin (CT) can also be produced by calcitonin gene-related peptide (CGRP), an alternative product of the calcitonin gene. This might be mediated by interaction of CGRP at the CT-receptor site. The human breast cancer cell line T47D possesses well characterized CT-receptors (KD = 2.3 x 10(-10) M for 125I salmon CT).
F, Raue, H G, Schneider, A, Zink, R, Ziegler   +3 more
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Interaction of Calcitonin and Calcitonin Gene-Related Peptide at Receptor Sites in Target Tissues

Science, 1985
Discrete receptor sites for calcitonin (CT) and calcitonin gene-related peptide (CGRP) were found in the nervous system and in peripheral tissues. Each peptide was capable of cross-reacting with the specific receptor of the other. In contrast to CT receptors, CGRP receptors were not linked to adenylate cyclase.
D, Goltzman, J, Mitchell
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Calcitonin, calcitonin gene-related peptide and renal calcitonin receptors in the Zucker rat.

Bone and mineral, 1989
In this study we investigated (a) whether genetically obese Zucker rats exhibit higher levels of calcitonin gene-related peptide (CGRP) in the thyroid and plasma than lean controls, (b) if CGRP, like calcitonin (CT), increases in plasma in response to iv Ca or iv pentagastrin and (c) whether or not renal CT receptors exhibit 'downregulation' in fat ...
P K, Seitz, C W, Cooper
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Pharmacology of receptors for calcitonin gene-related peptide and amylin

Trends in Pharmacological Sciences, 1995
Calcitonin gene-related peptide (CGRP), a widespread neuropeptide with multiple actions, has substantial homology with amylin, a peptide implicated in insulin-resistant diabetes, and adrenomedullin, a recently discovered potent vasodilator. There is controversy over the existence of CGRP receptor subtypes, and whether independent receptors exist for ...
openaire   +2 more sources

Regulation of signal transduction by calcitonin gene-related peptide receptors

Trends in Pharmacological Sciences, 2010
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-coupled receptor (GPCR), a single transmembrane protein, and an additional protein that is required for Gα(s) coupling.
Christopher S, Walker, Alex C, Conner, David R, Poyner, Debbie L, Hay   +3 more
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Calcitonin gene-related peptide receptor antagonists for migraine

Expert Opinion on Investigational Drugs, 2010
Migraine is a highly prevalent disabling condition, and the current treatment options are not satisfactory. The role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology is well established. CGRP receptor antagonists address this new target and have the potential to improve therapy for both responders and non-responders to previous ...
openaire   +2 more sources

Specific Receptor and Cardiovascular Effects of Calcitonin Gene-Related Peptide*

Endocrinology, 1986
Specific binding sites for calcitonin gene-related peptide (CGRP) were demonstrated in the rat heart and spleen. Autoradiography revealed rat [125I]iodo CGRP binding associated with the intima and media of the aorta, the coronary arteries and the heart valves, and the red pulp of the spleen.
S, Sigrist, A, Franco-Cereceda, R, Muff, H, Henke, J M, Lundberg, J A, Fischer   +5 more
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Macrophages express functional receptors for calcitonin‐gene‐related peptide

Journal of Cellular Physiology, 1991
AbstractThe present study was designed to investigate whether non‐activated macrophages express calcitonin (CT) or calcitonin‐gene‐related peptide (CGRP) receptors. To this end, we first analyzed whether CT and CGRP induce a cAMP accumulation in macrophages.
A, Vignery, F, Wang, M B, Ganz
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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2021
Calcitonin gene-related peptide (CGRP) receptor antagonists have been shown clinically to be effective treatments for migraine. Zavegepant (BHV-3500, BMS-742413) is a high affinity antagonist of the CGRP receptor (hCGRP Ki = 0.023 nM) that has demonstrated efficacy in the acute treatment of migraine with intranasal delivery in a Phase 2/3 trial ...
Stephen E, Mercer, Prasad V, Chaturvedula, Charles M, Conway, Deborah A, Cook, Carl D, Davis, Sokhom S, Pin, Robert, Macci, Richard, Schartman, Laura J, Signor, Kimberly A, Widmann, Valerie J, Whiterock, Ping, Chen, Cen, Xu, John J, Herbst, Walter A, Kostich, George, Thalody, John E, Macor, Gene M, Dubowchik   +17 more
openaire   +2 more sources