Results 61 to 70 of about 9,580 (229)

VITAMIN D3: RESEARCH BREAKTHROUGHS AND THERAPEUTIC USE [PDF]

Annals of Mechnikov's Institute, 2017
Vitamin D3 (cholecalciferol), the natural form of vitamin D, is produced in the skin from 7-dehydrocholesterol. The synthesis of vitamin D in the skin is the most important source of vitamin D.
Pohorila М.S., Martynov A.V., Romanova E.А., Іgumnova N.І., Sidorenko Т.А., Yukhimenko V.І., Shcherbak O.M.   +6 more
doaj   +1 more source

The musculoskeletal system diseases in pregnant women with high infection risk and the single nucleotide rs1544410 polymorphism of the calcitriol receptor gene

Bolʹ, Sustavy, Pozvonočnik, 2023
Background. The problem of vitamin D (VD) deficiency in the population, in general, and in pregnant women, in particular, and related diseases, including the musculoskeletal system, remains one of the most widespread medical and social problems of our ...
G.S. Manasova, N.V. Didenkul, O.V. Zhovtenko, S.V. Derishov, Z.V. Chumak   +4 more
doaj   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Enhanced Antiproliferative Effect of Combined Treatment with Calcitriol and All-Trans Retinoic Acid in Relation to Vitamin D Receptor and Retinoic Acid Receptor α Expression in Osteosarcoma Cell Lines

, 2020
The main objective of this study was to analyze changes in the antiproliferative effect of vitamin D3, in the form of calcitriol and calcidiol, via its combined application with all-trans retinoic acid (ATRA) in osteosarcoma cell lines.
Dalibor Valik, Jaroslav Sterba, Renata Veselska, Silvia Paukovcekova   +3 more
core   +1 more source

Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters [PDF]

, 2022
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is involved in the regulation of enzymes, transporters and receptors, and therefore intimately affects drug ...
Noh, Keumhan, Quach, Holly P., Tirona, Rommel G., Pang, K. Sandy, Chow, Edwin C.Y., Groothuis, Geny M.M.   +5 more
core   +1 more source

Conservative treatment of bone tissue metabolic disorders among patients with vitamin D-dependent rickets type II with genetic abnormality of type I collagen formation

Bolʹ, Sustavy, Pozvonočnik, 2017
Background. The purpose of the article is to determine the effect of conservative therapy on genetically caused disorders of bone tissue metabolism in patients with vitamin D-dependent rickets type II and genetic abnormality of type I collagen formation (
S.M. Martsyniak
doaj   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Vitamin D Receptor mRNA Measured in Leukocytes with the TaqMan Fluorogenic Detection System: Effect of Calcitriol Administration [PDF]

Clinical Chemistry, 2004
AbstractBackground: The aim of the present study was to investigate the interactions between the circulating concentrations of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and the mRNA concentration of its specific nuclear receptor in human leukocytes.Methods: We measured vitamin D receptor (VDR) mRNA extracted from leukocytes by use of TaqMan fluorescence ...
Soldati L, Adamo D, Bianchin C, Arcidiacono T, Terranegra A, Bianchi ML, Mora Stefano, Cusi D, Vezzoli G   +8 more
openaire   +3 more sources

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Calcemic response to parathyroid hormone in renal failure: Role of phosphorus and its effect on calcitriol

, 1991
Calcemic response to parathyroid hormone in renal failure: Role of phosphorus and its effect on calcitriol. The Calcemic response to parathyroid hormone (PTH) is decreased in renal failure.
Rodriguez, Mariano, Martinez, Maria E., Llach, Francisco, Martin-Malo, Alejandro, Felsenfeld, Arnold J., Torres, Armando   +5 more
core   +1 more source