Results 51 to 60 of about 9,580 (229)

Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients

Frontiers in Pharmacology, 2018
Bile acids (BAs) are amphiphilic molecules with 24 carbon atoms and consist of a hydrophobic and a rigid steroid nucleus, to which are attached a hydrophilic hydroxyl group and a flexible acidic aliphatic side chain. The steroidal core of BAs constitutes
Tanja M. Šarenac, Momir Mikov
doaj   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Regulation of Prostaglandin Metabolism by Calcitriol Attenuates Growth Stimulation in Prostate Cancer Cells

, 2005
Calcitriol exhibits antiproliferative and prodifferentiation effects in prostate cancer. Our goal is to further define the mechanisms underlying these actions. We studied established human prostate cancer cell lines and primary prostatic epithelial cells
Donna M. Peehl, David Feldman, Jacqueline Moreno, Aruna V. Krishnan, Srilatha Swami, Larisa Nonn   +5 more
core   +1 more source

Functional Calcitriol/Vitamin D Receptor Signaling in Chronic Lymphocytic Leukemia

Blood, 2019
Calcitriol, the biologically active form of vitamin D, modulates a plethora of cellular processes following its receptor ligation, namely the vitamin D receptor (VDR), a nuclear transcription factor that regulates the transcription of diverse genes.
Marina Gerousi, Fotis Psomopoulos, Kostantia Kotta, Niki Stavroyianni, Achilles Anagnostopoulos, Ioannis Kotsianidis, Stavroula Ntoufa, Kostas Stamatopoulos   +7 more
openaire   +1 more source

Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients

BMC Nephrology, 2012
Background Treatment with selective vitamin D receptor activators such as paricalcitol have been shown to exert an anti-inflammatory effect in patients on hemodialysis, in addition to their action on mineral metabolism and independently of parathyroid ...
Izquierdo María, Cavia Mónica, Muñiz Pilar, de Francisco Angel LM, Arias Manuel, Santos Javier, Abaigar Pedro   +6 more
doaj   +1 more source

Vitamin D Supplementation to Prevent Post‐Thyroidectomy Hypocalcemia

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Hypocalcemia is the most common complication following thyroidectomy. Previous studies yielded inconsistent results on whether vitamin D3 prevents postoperative hypocalcemia and were conducted in non‐European countries with different dietary habits and baseline vitamin D levels.
Jeresa I. A. Willems, Daan J. L. van Twist, Kristy M. Pickwell, Patrick L. H. van Battum, Rutgert Bianchi, Annette M. Pijnenburg, James van Bastelaar, Marco Medici, Robin P. Peeters, Roderick F.A. Tummers‐de Lind van Wijngaarden   +9 more
wiley   +1 more source

Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D

, 2022
The active forms of vitamin D3 (calcitriol and tacalcitol) coupled to the vitamin D receptor (VDR) are known to exhibit anti-cancer properties. However, not all cancer cells are sensitive to the active forms of vitamin D3 and its analogs. The study aimed
Katarzyna Gębura, Andrzej Kutner, Dagmara Kłopotowska, Eliza Turlej, Joanna Wietrzyk, Karolina Anna Mielko, Justyna Joanna Gleba, Joanna Banach, Katarzyna Bogunia-Kubik   +8 more
core   +1 more source

Effect of Two Therapeutic Renal Diets on Hormonal and Regulatory Pathways Affecting Calcium Homeostasis in Cats With Early‐Stage Chronic Kidney Disease

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall, Elizabeth M. Morris, Dale A. Fritsch, John J. Brejda, Kim M. Wilson   +4 more
wiley   +1 more source

Relationship between vitamin D deficiency and early implant failure and osseointegration

Periodontology 2000, EarlyView.
Abstract Background This systematic review investigated the relationship between pre‐operative vitamin D levels and implant osseointegration and implant‐related outcomes. It also assessed studies involving vitamin D supplementation before implant placement.
Richard J. Miron, Nathan E. Estrin, Ana Paz, Reinhard Gruber, Nima Farshidfar, Yufeng Zhang, Anton Sculean, Thomas G. Wiedemann, Paras Ahmad   +8 more
wiley   +1 more source

Effect of Calcitriol and Vitamin D Receptor Modulator 2 on Recovery of Injured Skeletal Muscle in Wistar Rats

Biomedicines, 2023
Muscle injuries often result in functional limitations due to insufficient healing. This study assessed the influence of calcitriol and vitamin D Receptor Modulator 2 (VDRM2) on muscle regeneration in male Wistar rats following open blunt muscle injury.
Ioannis Stratos, Svenja Schleese, Ingmar Rinas, Brigitte Vollmar, Thomas Mittlmeier   +4 more
openaire   +3 more sources