Results 41 to 50 of about 9,580 (229)
Putative helices 3 and 5 of the human vitamin D3 receptor are important for the binding of calcitriol [PDF]
FEBS Letters, 1998 We have introduced eleven point mutations into the human vitamin D receptor by site‐directed mutagenesis in order to identify some of the amino acid residues that are important for ligand binding. The amino acid residues Ser225, His229, Asp232, Val234, Ser235, Tyr236, Ser237, Lys240, Ile242, Lys246 (helix 3), and Ser275 (helix 5) of the human vitamin D
Väisänen, Sami +2 more
openaire +2 more sources
PLoS ONE, 2022 Pregnancy induces maternal renal adaptations that include increased glomerular filtration rate and renal blood flow which can be compromised in obstetrical complications such as preeclampsia.
Zhong Chen +4 more
doaj +2 more sources
Angewandte Chemie International Edition, EarlyView.Vitamin D exhibits complex and cell‐specific biological effects in multiple tissues via activation of the ligand‐sensing transcription factor vitamin D receptor (VDR). The photo‐switchable vitamin D mimetic 10 transitions between VDR antagonist (E) and agonist (Z) activity upon illumination and offers unprecedented bidirectional optical control over ...
Xiu Ge +11 more
wiley +1 more source
, 1996 Coordinate regulation of PTH/PTHrP receptors by PTH and calcitriol in UMR 106-01 osteoblast-like cells. High levels of PTH result in desensitization of target cells to further stimulation with PTH in vivo and in vitro.
Martin, Kevin J., González, Esther A.
core +1 more source
Arthritis &Rheumatology, Accepted Article.Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway +13 more
wiley +1 more source
Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins. [PDF]
Journal of Clinical Investigation, 1995 The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs). Although renal failure is associated with resistance to the action of calcitriol, the mechanism of this resistance is not well understood.
S R, Patel +4 more
openaire +2 more sources
The health benefits of vitamin D relevant for tuberculosis [PDF]
Journal of Medical Biochemistry, 2014 Vitamin D has an important role in numerous physiological functions. Vitamin D receptors are characterized by polymorphisms and presence in different tissues including a number of cells of the immune system.
Škodrić-Trifunović Vesna +7 more
doaj
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
, 1991 Calcemic response to parathyroid hormone in renal failure: Role of calcitriol and the effect of parathyroidectomy. Hyperparathyroidism due to renal failure begins in the early stages of renal insufficiency and is in part secondary to skeletal resistance ...
Rodriguez, Mariano +2 more
core +1 more source
Rheumatology &Autoimmunity, EarlyView.Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs +5 more
wiley +1 more source