Heroin Adulterated with the Novel Synthetic Cannabinoid, 5F-MDMB-PINACA: A Case Series [PDF]
, 2020 Introduction: Heroin can be adulterated with various substances that may or may not have pharmacological effects. Here we report a case series of 8 patients who presented to the emergency department after overdose with intravenous heroin preparation ...
Arnold, Ryan +5 more
core
The synthetic cannabinoids menace: a review of health risks and toxicity
European Journal of Medical ResearchSynthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe enough to damage the normal ...
Ayman Alzu’bi +5 more
doaj +1 more source
The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Brazilian Journal of PsychiatryObjective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much ...
Eduardo S. Gouvêa +7 more
doaj +1 more source
Update on the Role of Cannabinoid Receptors after Ischemic Stroke
Mediators of Inflammation, 2012 Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial ...
Luciano S. A. Capettini +6 more
doaj +1 more source
The development and therapeutic potential of classical and next-generation cannabinoid ligands
Pharmacological ResearchThe endogenous cannabinoid system (ECS) is a complex network that plays a crucial role in various physiological processes, and its modulation through cannabinoid ligands has garnered significant interest in pharmacological research. Cannabinoid receptors,
Verónica Muñoz-Canales +4 more
doaj +1 more source
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. [PDF]
, 2018 Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side effect of cancer treatment that affects millions of cancer survivors throughout the world and current treatment options are extremely limited by their side effects ...
Mackie, Ken +6 more
core +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources
Cannabinoid CB1 receptor; cannabinoid CB2 receptor [PDF]
Science-Business eXchange, 2008 openaire +1 more source
Direct modulation of human GABA-A α<sub>1</sub>β<sub>2</sub>γ<sub>2</sub> receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development. [PDF]
Front NeurosciMixcoha E +4 more
europepmc +1 more source
Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders. [PDF]
BiomedicinesFaganeli D, Lipnik-Stangelj M.
europepmc +1 more source