Results 81 to 90 of about 579,297 (292)

Aspectos terapêuticos de compostos da planta Cannabis sativa

open access: yesQuímica Nova, 2006
Several cannabinoid compounds present therapeutic properties, but also have psychotropic effects, limiting their use as medicine. Nowadays, many important discoveries on the compounds extracted from the plant Cannabis sativa (cannabinoids) have ...
Honório Káthia Maria   +2 more
doaj  

Cannabinoids and Innate Immunity: Taking a Toll on Neuroinflammation

open access: yesThe Scientific World Journal, 2011
The biologically active components of cannabis have therapeutic potential in neuroinflammatory disorders due to their anti-inflammatory propensity. Cannabinoids influence immune function in both the peripheral and the central nervous system (CNS), and ...
Eric J. Downer
doaj   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures [PDF]

open access: yes, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core  

Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca

open access: yes, 2021
Synthetic cannabinoids have emerged as novel psychoactive substances with damaging consequences for public health. They exhibit high affinity at the cannabinoid type-1 (CB1) receptor and produce similar and often more potent effects as other CB1 receptor
MARSICANO, Giovanni   +17 more
core   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

open access: yesPhytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca   +5 more
wiley   +1 more source

Cannabinoids and alcohol co-exposure modulate pathogen-induced pulmonary immune responses

open access: yesFrontiers in Immunology
Both alcohol and cannabinoid misuse cause substantial societal problems individually, and cannabis is the most popular illicit drug used simultaneously with alcohol.
De’Jana Parker, Vijay Sivaraman
doaj   +1 more source

The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications

open access: yesNeural Plasticity, 2016
Cannabis is one of the most prevalent drugs used in industrialized countries. The main effects of Cannabis are mediated by two major exogenous cannabinoids: ∆9-tetrahydroxycannabinol and cannabidiol.
Thomas Schwitzer   +4 more
doaj   +1 more source

Cannabinoid Ligands Targeting TRP Channels

open access: yesFrontiers in Molecular Neuroscience, 2019
Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli.
Chanté Muller   +2 more
doaj   +1 more source

The Role of Repetitive Transcranial Magnetic Stimulation in Modulating Autonomic Dysfunction in Irritable Bowel Syndrome rTMS for IBS Autonomic Dysfunction

open access: yesSensory Neuroscience, EarlyView.
Irritable bowel syndrome (IBS) is associated with dysregulation of the autonomic nervous system and altered brain–gut communication. rTMS may alleviate IBS symptoms by modulating central autonomic and pain‐processing networks, potentially restoring sympathovagal balance and reducing visceral hypersensitivity.
Aliasghar Karimi   +4 more
wiley   +1 more source

Interspecies differences in the expression of cannabinoid receptors at the tissue and cellular levels

open access: yesNeural Regeneration Research
Understanding the cellular and molecular distribution of cannabinoids can address a highly contentious perspective in the pain neuroscience field: whether cannabinoids are viable in pain relief.
Sydney Lawley   +3 more
doaj   +1 more source

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