Results 91 to 100 of about 57,210 (209)

Cannabinoid Ligands Targeting TRP Channels

Frontiers in Molecular Neuroscience, 2019
Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli.
Chanté Muller, Paula Morales, Patricia H. Reggio   +2 more
doaj   +1 more source

Interspecies differences in the expression of cannabinoid receptors at the tissue and cellular levels

Neural Regeneration Research
Understanding the cellular and molecular distribution of cannabinoids can address a highly contentious perspective in the pain neuroscience field: whether cannabinoids are viable in pain relief.
Sydney Lawley, Audrey Green, Cole Johnson, Michael D. Burton   +3 more
doaj   +1 more source

Cannabinoids and Pain

Pain Research and Management, 2001
Cannabinoids have been used to treat pain for many centuries. However, only during the past several decades have rigorous scientific methods been applied to understand the mechanisms of cannabinoid action.
J Michael Walker, Nicole M Strangman, Susan M Huang   +2 more
doaj   +1 more source

Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]

, 2012
This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J., Kreutter, M., LaCourt, M., Mantsch, John R., Stroh, G., Vaughn, Linda K., Vranjkovic, Oliver   +6 more
core   +2 more sources

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]

, 2017
N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith, Lawton, Samira K, Prakash, Arun, Schumacher, Mark, Tran, Alphonso, Wilhelmsen, Kevin, Wong, Erika, Xu, Fengyun   +7 more
core   +2 more sources

Computer modeling of Cannabinoid receptor type 1

ITM Web of Conferences, 2018
Cannabinoid receptors are important class of receptors as they are involved in various physiological processes such as appetite, pain-sensation, mood, and memory.
Sapundzhi Fatima, Dzimbova Tatyana, Pencheva Nevena, Milanov Peter   +3 more
doaj   +1 more source

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences, 2004
Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
doaj   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

Biochemistry of the Endogenous Ligands of Cannabinoid Receptors

Neurobiology of Disease, 1998
In 1992 the discovery of the first endogenous ligand of cannabinoid receptors, anandamide, provided conclusive support to the hypothesis that an “endogenous cannabinoid regulatory system” exists in mammalian nervous tissue.
Vincenzo Di Marzo, Dale G. Deutsch
doaj   +1 more source

The Medicalization of Cannabis [PDF]

, 2010
Annotated and edited transcript of a Witness Seminar held on 24 March 2009. Introduction by Professor Leslie Iversen.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010.©The Trustee of the Wellcome Trust, London, 2010 ...
Crowther, SM, Reynolds, LA, Tansey, EM
core