Results 141 to 150 of about 28,855 (210)

Mitochondrial dysfunction and autophagy activation underlie NK cell impairment induced by Cannabis. [PDF]

PLoS One
Bolduc AA, Tremblay T, Almutairi MH, Semlali A, Loubaki L.   +4 more
europepmc   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder. [PDF]

Front Psychiatry
Zhang G, Hu Q, Zou H.
europepmc   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Dynamic mechanism for subtype selectivity of endocannabinoids. [PDF]

J Biol Chem
Dutta S, Zhao L, Shukla D.
europepmc   +1 more source

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling Pathway

MedComm, Volume 7, Issue 8, August 2026.
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa, Alba Cabaleiro, Borja López‐Picallo, Natalia da Silva Lima, Cristina Riobello, Carmen Pena, Jose Iglesias‐Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernandez‐Iglesias, Jordi Gracia‐Sancho, Susana Bravo, Carlos Dieguez, Marta Varela‐Rey, Vincent Prevot, Markus Schwaninger, Miguel López, Rubén Nogueiras   +17 more
wiley   +1 more source

Dissecting GPCR Contributions to Gαo-Dependent Motor Dysfunction in <i>GNAO1</i>-Related Disorders Using <i>Caenorhabditis elegans</i>. [PDF]

Biomedicines
Di Rocco M, Di Rienzo L, Follo FC, D'Alessandro M, Galosi S, Pannone L, Venanzi S, Di Schiavi E, Martire A, Bessereau JL, Leuzzi V, Milanetti E, Martinelli S.   +12 more
europepmc   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Potential antitumor effect of cannabidiol (CBD) in canine oncology: a systematic review. [PDF]

Front Vet Sci
Medina FJ, Torres CG.
europepmc   +1 more source

Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis

The Journal of Pathology, Volume 269, Issue 4-5, Page 462-477, August 2026.
Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu, Karina Cárdenas‐Jaen, Enrique de‐Madaria, José María Hernández, Lourdes Fluvià, Laura Torres‐Ribas, Daniel Closa, Raquel Guillamat‐Prats   +7 more
wiley   +1 more source