Results 171 to 180 of about 56,351 (295)

The art of tolerance [PDF]

, 1998
M Terakura, N Murase, P Aichele, PS Ohashi, RE Billingham, RM Zinkernagel, RM Zinkernagel, RM Zinkernagel, S Qian, TE Starzl, TE Starzl, Thomas Starzl, TM Kundig   +12 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer's disease: a review. [PDF]

Front Pharmacol
Ntsapi C, Weyers M, Chinheya R, Jim T, Matsabisa M.   +4 more
europepmc   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Cannabidiol-Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma. [PDF]

Pathophysiology
Chávez-López MG, Avalos-Fuentes A, Cruz-Manzo EDC, Aguirre-Arriaga PA, Florán B, Pérez-Carreón JI, Bañuelos C, Camacho J.   +7 more
europepmc   +1 more source

Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity. [PDF]

FASEB J
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Palaniappan S, Tisi A, Di Meo C, Urbano C, Fenton GE, Della Valle F, Fanti F, Compagnone D, Nazarè M, Versnel H, Aramini A, Allegretti M, Maccarrone M.   +12 more
europepmc   +2 more sources

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation. Studies suggest that compound cytotoxicity profiles in vitro vary depending on FCS concentration in culture medium. The study aimed to examine how extracellular conditions influence the in vitro
Sanele Priscillia Mathibela, Maphuti Tebogo Lebelo, Vanessa Steenkamp   +2 more
wiley   +1 more source

Toxicity and health effects of delta-8, delta-9, and delta-10-tetrahydrocannabinol and unregulated cannabinoids in vaping products. [PDF]

Toxicol Rep
Lin K, Sun Y, Raghu R, Suharu P, Effah F, Rahman I.   +5 more
europepmc   +1 more source

Cannabichromene variation in hemp cultivars

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Cannabichromene (CBC) is a nonpsychoactive cannabinoid with pharmaceutical potential that is attracting significant interest for its potential therapeutic applications. However, the factors governing CBC production in Cannabis sativa remain largely unknown. This study aimed to investigate the variation in CBC accumulation within different Type
Anthony Torres, Caleb King, Christopher S. Pauli, Thomas Blank, Donald P. Land, Kymron DeCesare, Reggie Gaudino   +6 more
wiley   +1 more source

The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract. [PDF]

World J Urol
Ückert S, Hedlund P, Tsikas D, Kuczyk MA.   +3 more
europepmc   +1 more source