Results 11 to 20 of about 28,855 (210)
Frontiers in Veterinary Science, 2022 It is commonly accepted that some form of skin barrier dysfunction is present in canine atopic dermatitis (AD), one of the most common cutaneous pruritic inflammatory diseases of dogs.
Roberto Chiocchetti +7 more
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Neural Plasticity, 2016 Neurocognitive effects of cannabinoids have been extensively studied with a focus on CB1 cannabinoid receptors because CB1 receptors have been considered the major cannabinoid receptor in the nervous system. However, recent discoveries of CB2 cannabinoid
Yong Li, Jimok Kim
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The Functional Neuroanatomy of Brain Cannabinoid Receptors
Neurobiology of Disease, 1998 The effects of the primary psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol, are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique central nervous system (CNS) distribution and are present in mammalian brain
Christopher S. Breivogel +1 more
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Effects of endocannabinoid system modulation on cognitive and emotional behavior
Frontiers in Behavioral Neuroscience, 2011 Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive ...
Claudio eZanettini +5 more
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New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
Frontiers in Pharmacology, 2020 Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid ...
Agustín Riquelme-Sandoval +7 more
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Frontiers in Veterinary Science, 2019 Growing evidence indicates cannabinoid receptors as potential therapeutic targets for chronic pain. Consequently, there is an increasing interest in developing cannabinoid receptor agonists for treating human and veterinary pain. To better understand the
Roberto Chiocchetti +9 more
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Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors
Communications Biology, 2023 Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB1 and CB2).
Soumajit Dutta, Diwakar Shukla
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Suppression of STAT3 Signaling by Δ9-Tetrahydrocannabinol (THC) Induces Trophoblast Dysfunction
Cellular Physiology and Biochemistry, 2017 Aims: Marijuana is a widely used illicit drug and its consumption during pregnancy has been associated with adverse reproductive outcomes. The purpose of this study was to determine the effects of chronic intake of Δ9-tetrahydrocannabinol (THC), the ...
Xinwen Chang +7 more
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Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors. [PDF]
PLoS ONE, 2012 The cannabinoid system is known to be involved in the regulation of inflammatory processes. Therefore, drugs targeting cannabinoid receptors are considered as candidates for anti-inflammatory and tissue protective therapy.
Svantje Tauber +6 more
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Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Frontiers in Pharmacology, 2015 The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
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