Results 1 to 10 of about 25,784 (209)

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3 [PDF]

Cell Discovery, 2022
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen   +21 more
doaj   +2 more sources

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis [PDF]

mBio
Infection by Mycobacterium tuberculosis (Mtb) continues to cause more than 1 million deaths annually, due to pathogen persistence in lung macrophages and dendritic cells derived from blood monocytes.
Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst   +3 more
doaj   +2 more sources

Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]

PLoS Computational Biology, 2018
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann   +2 more
doaj   +1 more source

Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events

Viruses, 2022
Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins.
Alexandre P. Fernandes, Ana Águeda-Pinto, Ana Pinheiro, Hugo Rebelo, Pedro J. Esteves   +4 more
doaj   +1 more source

Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. [PDF]

PLoS ONE, 2012
The chemokine receptors CCR2 and CX3CR1 are critical for the recruitment of "inflammatory" and "resident" monocytes, respectively, subpopulations that differentially affect vascular remodeling in atherosclerosis.
Joshua K Meisner, Ji Song, Richard J Price   +2 more
doaj   +1 more source

Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study. [PDF]

PLoS ONE, 2012
Chemokine receptors are G protein-coupled receptors that contain seven transmembrane domains. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple ...
Gugan Kothandan, Changdev G Gadhe, Seung Joo Cho   +2 more
doaj   +1 more source

Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. [PDF]

PLoS ONE, 2010
Monocyte subpopulations distinguished by differential expression of chemokine receptors CCR2 and CX3CR1 are difficult to track in vivo, partly due to lack of CCR2 reagents.We created CCR2-red fluorescent protein (RFP) knock-in mice and crossed them with ...
Noah Saederup, Astrid E Cardona, Kelsey Croft, Makiko Mizutani, Anne C Cotleur, Chia-Lin Tsou, Richard M Ransohoff, Israel F Charo   +7 more
doaj   +1 more source

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. [PDF]

PLoS ONE, 2015
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways ...
Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger   +8 more
doaj   +1 more source

Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis. [PDF]

PLoS ONE, 2011
BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model ...
Maria C Lebre, Clarissa E Vergunst, Ivy Y K Choi, Saïda Aarrass, Ana S F Oliveira, Tim Wyant, Richard Horuk, Kris A Reedquist, Paul P Tak   +8 more
doaj   +1 more source

Chemokine Receptors—Structure-Based Virtual Screening Assisted by Machine Learning

Pharmaceutics, 2023
Chemokines modulate the immune response by regulating the migration of immune cells. They are also known to participate in such processes as cell–cell adhesion, allograft rejection, and angiogenesis.
Paulina Dragan, Matthew Merski, Szymon Wiśniewski, Swapnil Ganesh Sanmukh, Dorota Latek   +4 more
doaj   +1 more source