Results 121 to 130 of about 25,784 (209)
Advanced Science, Volume 13, Issue 7, 3 February 2026.Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong +22 more
wiley +1 more source
Targeting CCR2 Receptor To Treat Inflammation Diseases and Disorders [PDF]
ACS Medicinal Chemistry Letters, 2013 openaire +2 more sources
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 363-378, February 2026.The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Catarina M. Gomes +4 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.After spinal cord injury (SCI), TREM2 promotes myelin debris clearance and disease‐associated microglia (DAM) activation that support early repair. However, sustained TREM2‐dependent DAM activation may aggravate chronic inflammation and fibrosis, whereas TREM2 deficiency alleviates these effects, identifying TREM2 as a key regulator of microglial ...
Zhonghan Wu +12 more
wiley +1 more source
A Novel Murine Model of Hemophagocytic Lymphohistiocytosis‐Like Inflammation in ZNFX1 Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.LCMV‐infected Znfx1‐deficient mice develop hemophagocytic lymphohistiocytosis (HLH)‐like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1‐deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages ...
Diana Tintor +9 more
wiley +1 more source
Chemokine (C-C motif) receptor 2 (CCR2) [PDF]
Science-Business eXchange, 2009 openaire +1 more source
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
Beyond lipids: Systemic effects of lipoprotein apheresis
Transfusion, EarlyView.
Menatalla Nadim, Yamac Akgun
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao +8 more
wiley +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source