Results 251 to 260 of about 43,606 (294)

CCR2 chemokine receptor and AIDS progression

Nature Medicine, 1997
Recently we reported an association between the CCR2-64I chemokine receptor mutation and delayed onset of AIDS. Michael et al. have now examined the San Francisco Mens Health Study (SFMHS) AIDS cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the CCR2-64I association.
Smith, Michael W., Carrington, Mary, Winkler, Cheryl, Lomb, Deborah A., Dean, Michael, Huttley, Gavin A., O'Brien, Stephen J.   +6 more
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Homology modeling of human CCR2 receptor

Medicinal Chemistry Research, 2010
Homology model of CCR2 receptor was built on the basis of the crystal structure of human beta-2 adrenoceptor (PDB ID-2RH1). The model showed 99.3% residues in the core and allowed regions of the Ramachandran plot and there was no residue present in the disallowed regions.
Rajesh Singh, M. Elizabeth Sobhia
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PCSK9 regulates the chemokine receptor CCR2 on monocytes

Biochemical and Biophysical Research Communications, 2017
Monocyte migration is a key element in atherosclerosis. LDL-C facilitates monocyte migration via induction of CCR2. PCSK9 regulates cell surface expression of the LDL-R and is expressed in vascular smooth muscle cells (VSMCs). The present study was done to investigate the regulation of PCSK9 in VSMCs and its impact on monocyte function.PCSK9 mRNA and ...
Jana, Grune, Heike, Meyborg, Taisiya, Bezhaeva, Kai, Kappert, Philipp, Hillmeister, Ulrich, Kintscher, Burkert, Pieske, Philipp, Stawowy   +7 more
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Chemokine receptor CCR2 involvement in skeletal muscle regeneration

The FASEB Journal, 2004
ABSTRACT Chemokines, signaling through the CCR2 receptor, are highly expressed in injured skeletal muscle. Their target specificity depends on the cellular expression of the specific receptors. Here we demonstrate that, in freeze‐injured muscle, CCR2 co‐localized with Mac‐3, a marker of activated macrophages as well as with myogenin ...
Gordon L, Warren, Tracy, Hulderman, Dawn, Mishra, Xin, Gao, Lyndell, Millecchia, Laura, O'Farrell, William A, Kuziel, Petia P, Simeonova   +7 more
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Chemokine receptor CCR2 undergoes transportin1‐dependent nuclear translocation

PROTEOMICS, 2008
Abstract Chemokines (CCs) are small chemoattractant cytokines involved in a wide variety of biological and pathological processes. Released by cells in the milieu, and extracellular matrix and activating signalling cascades upon binding to specific G protein‐coupled receptors (GPCRs), they trigger many cellular events.
Nicolas, Favre, Montserrat, Camps, Christian, Arod, Christian, Chabert, Christian, Rommel, Christian, Pasquali   +5 more
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Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2007
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).
Anthony B, Pinkerton, Dehua, Huang, Rowena V, Cube, John H, Hutchinson, Mary, Struthers, Julia M, Ayala, Pasquale P, Vicario, Sima R, Patel, Thomas, Wisniewski, Julie A, DeMartino, Jean-Michel, Vernier   +10 more
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The CCR2 receptor as a therapeutic target

Expert Opinion on Therapeutic Patents, 2005
The strict control of cell recruitment during the physiological inflammatory response fails in autoimmune inflammatory diseases. The chemokine system is a complex and redundant network of small soluble proteins and G-protein-coupled cell surface receptors that participate in the inflammatory response, mainly attracting cells to the inflammatory foci ...
Manuel Feria, Federico Díaz-González
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Implication of CCR2 Chemokine Receptor in Cocaine-Induced Sensitization

Journal of Molecular Neuroscience, 2011
Cocaine-induced sensitization induces long-term neuroplastic changes in the striatum. Among these, extracellular signal-regulated kinase (ERK) is a fundamental component in striatal gene and epigenetic regulation and plays an important role in reward processes. As previous studies suggested that the chemokine CCL2 enhanced striatal dopamine release and
Trocello, Jean Marc, Rostène, William, Melik-Parsadaniantz, Stéphane, Godefroy, David, Roze, Emmanuel, Kitabgi, Patrick, Kuziel, William, Chalon, Sylvie, Caboche, Jocelyne, Apartis, Emmanuelle   +9 more
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CCR2: A characteristic chemokine receptor in normal and pathological intestine

Cytokine, 2023
C-C motif chemokine receptor 2 (CCR2), together with its ligands, especially C-C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in vivo environment. Scientometric methods are used to analyze intestine-related CCR2 expression.
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Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

Clinical Science, 2017
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16−CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes ...
Carolina N, França, Maria C O, Izar, Marinella N S, Hortêncio, Jônatas B, do Amaral, Carlos E S, Ferreira, Izabela D, Tuleta, Francisco A H, Fonseca   +6 more
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