Results 261 to 270 of about 43,606 (294)
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Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis
European Journal of Neurology, 2004The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2–CCR2 axis are scarce in MS.
Sørensen, Torben Lykke +3 more
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Novel, Orally Bioavailable γ-Aminoamide CC Chemokine Receptor 2 (CCR2) Antagonists
Journal of Medicinal Chemistry, 2006Through modification of a screening hit we have discovered a structurally distinct new lead, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide (11), which has subsequently served as the departure point for an ongoing program targeting CCR2 antagonists.
Alexander, Pasternak +8 more
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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases
Archives of Pharmacal Research, 2013Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis
International Journal of Molecular Medicine, 2003The aim of this study was to examine the association of human autoimmune myasthenia gravis (MG) with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64I. CCR2 and CCR5 interact primarily with the human CC family ligands CCL2 (formerly called monocyte chemoattractant protein; MCP-1), CCL3 and CCL4 (macrophage inflammatory protein-
Xiaoyan, Zhao +6 more
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Molecular Modeling of Human CCR2 Receptor within POPC Lipid Bilayer
Structural Chemistry, 2016Chemokine receptor 2 (CCR2), a G-protein coupled receptor (GPCR), is a critical target for several inflammatory and autoimmune diseases. The main restriction on designing desirable antagonists against CCR2 is the lack of appropriate crystal structure for this target.
Ahmad Ebadi +4 more
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CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 in inflammation
2023The CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 (iCCRs) play a critical role in orchestrating the recruitment of leukocytes to inflamed areas. However, excessive leukocyte accumulation during inflammation can cause tissue damage and various inflammatory disorders, making iCCRs a promising target for therapeutic interventions.
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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
Bioorganic & Medicinal Chemistry Letters, 2009A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification of two distinct substitution patterns about the cyclohexane ring as potent and selective CCR2 antagonists.
Robert J, Cherney +9 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization
Letters in Drug Design & Discovery, 2007O. Dasse +14 more
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