Results 51 to 60 of about 43,606 (294)

Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE

Journal of Neuroinflammation, 2007
Background The CC chemokine receptors CCR1, CCR2 and CCR5 are critical for the recruitment of mononuclear phagocytes to the central nervous system (CNS) in multiple sclerosis (MS) and other neuroinflammatory diseases.
Ericsson-Dahlstrand Anders, Olsson Tomas, Nilsson Maria, Wallström Erik, Lassmann Hans, Berg Anna-Lena, Eltayeb Sana, Sunnemark Dan   +7 more
doaj   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

, 2023
AbstractBy driving monocyte chemotaxis, the chemokine receptor CCR2 shapes inflammatory responses and the formation of tumor microenvironments. This makes it a promising target in inflammation and immuno-oncology; however, despite extensive efforts, there are no FDA-approved CCR2-targeting therapeutics.
John R.D. Dawson, Grant M. Wadman, Penglie Zhang, Andrew Tebben, Percy H. Carter, Siyi Gu, Thomas Shroka, Leire Borrega-Roman, Catherina L. Salanga, Tracy M. Handel, Irina Kufareva   +10 more
openaire   +2 more sources

Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction [PDF]

Genes & Immunity, 2001
Our objective was to examine the association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of MI. A total of 214 patients with an age at the first MI episode
P, González, R, Alvarez, A, Batalla, J R, Reguero, V, Alvarez, A, Astudillo, G I, Cubero, A, Cortina, E, Coto   +8 more
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells.
S.M. Mohaddes Ardebili
doaj  

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 [PDF]

Proceedings of the National Academy of Sciences, 2003
Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a marked attenuation of monocyte recruitment in response to various inflammatory stimuli and a reduction of inflammatory lesions in models of demyelinating disease. In the present study, we compared nociceptive responses in inflammatory and neuropathic models of pain in
Catherine, Abbadie, Jill A, Lindia, Anne Marie, Cumiskey, Larry B, Peterson, John S, Mudgett, Ellen K, Bayne, Julie A, DeMartino, D Euan, MacIntyre, Michael J, Forrest   +8 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis

mBio
Infection by Mycobacterium tuberculosis (Mtb) continues to cause more than 1 million deaths annually, due to pathogen persistence in lung macrophages and dendritic cells derived from blood monocytes.
Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst   +3 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source