Results 51 to 60 of about 25,784 (209)

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

PLoS Biology, 2019
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee, Gillian J Wilson, Marieke Pingen, Ayumi Fukuoka, Christopher A H Hansell, Robin Bartolini, Laura Medina-Ruiz, Gerard J Graham   +7 more
doaj   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors

Molecular Pain, 2007
Background Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropathies ...
Monahan Patrick E, Li Baolin, Hamdouchi Chafiq, Lineswala Jayana, Henry Kenneth J, Miller Richard J, Ren Dongjun, Bhangoo Sonia, Chan David M, Ripsch Matthew S, White Fletcher A   +10 more
doaj   +1 more source

Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/Treponema pallidum Coinfection

Frontiers in Medicine, 2020
HIV-1/Treponema pallidum (T. pallidum) coinfection has become a global challenge, and three monocyte subsets express varying levels of the chemokine receptors CCR2 and CX3CR1.
Na Guo, Na Guo, Yongchang Chen, Yongchang Chen, Bin Su, Bin Su, Xiaodong Yang, Xiaodong Yang, Qiuyue Zhang, Qiuyue Zhang, Ting Song, Ting Song, Hao Wu, Hao Wu, Cuie Liu, Cuie Liu, Lifeng Liu, Lifeng Liu, Tong Zhang, Tong Zhang   +19 more
doaj   +1 more source

CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. [PDF]

PLoS ONE, 2014
The chemokine receptors CX3CR1 and CCR2 have been implicated in the development of age-related macular degeneration (AMD). The evidence is mainly derived from experimental cell studies and murine models of AMD.
Mads Krüger Falk, Amardeep Singh, Carsten Faber, Mogens Holst Nissen, Thomas Hviid, Torben Lykke Sørensen   +5 more
doaj   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Memorias do Instituto Oswaldo Cruz, 2016
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC).
Erinaldo Ubirajara Damasceno dos Santos, Géssica Dayane Cordeiro de Lima, Micheline de Lucena Oliveira, Sandra de Andrade Heráclio, Hildson Dornelas Angelo da Silva, Sergio Crovella, Maria de Mascena Diniz Maia, Paulo Roberto Eleutério de Souza/   +7 more
doaj   +1 more source

Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. [PDF]

PLoS ONE, 2014
Dendritic cells (DCs) play essential roles in both innate and adaptive immune responses. In addition, mutual regulation of the nervous system and immune system is well studied.
Norihisa Mikami, Kaori Sueda, Yusuke Ogitani, Ippei Otani, Miku Takatsuji, Yasuko Wada, Keiko Watanabe, Rintaro Yoshikawa, Satoshi Nishioka, Nagisa Hashimoto, Yayoi Miyagi, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa   +13 more
doaj   +1 more source

Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice [PDF]

The Journal of Immunology, 2001
AbstractThe chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages and T cells. To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans, we have generated mAbs against murine CCR2 and CCR5. In mice CCR2
M, Mack, J, Cihak, C, Simonis, B, Luckow, A E, Proudfoot, J, Plachý , H, Brühl, M, Frink, H J, Anders, V, Vielhauer, J, Pfirstinger, M, Stangassinger, D, Schlöndorff   +12 more
openaire   +2 more sources