The chemokine receptor, CCR5 [PDF]
The International Journal of Biochemistry & Cell Biology, 2004 The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
Mueller, A., Strange, P. G.
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Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO‐K1 cells [PDF]
British Journal of Pharmacology, 2008 Background and purpose:The CCR5 chemokine receptor is a member of the G protein‐coupled receptor (GPCR) family that is expressed by macrophages, memory T‐lymphocytes and dendritic cells and is activated by chemotactic proteins (e.g. MIP‐1α [CCL3], MIP‐1β [CCL4] and RANTES [CCL5]).
Longden, James, Cooke, E-L, Hill, SJ
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CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway [PDF]
Journal of Inflammation, 2009 Background Herpesviruses have evolved chemokines and chemokine receptors, which modulate the recruitment of human leukocytes during the inflammatory response to infection.
Gompels Ursula A +2 more
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The first structure of HIV-1 gp120 with CD4 and CCR5 receptors [PDF]
Cell & Bioscience, 2019 Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex.
Yongjun Guan
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Pharmacological characterization of the chemokine receptor, CCR5 [PDF]
British Journal of Pharmacology, 2002 We investigated the effects of a number of naturally occurring chemokines (MIP‐1α, MIP‐1β, RANTES, MCP‐2, MCP‐3, MCP‐4) on different processes linked to the chemokine receptor CCR5 in recombinant CHO cells expressing the receptor at different levels.
Mueller, Anja +4 more
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Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine–CCR5 interactions [PDF]
Antiviral Therapy, 2009 Background This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine–CCR5 interactions. Methods
Hirotomo, Nakata +7 more
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CCR5 is a potential therapeutic target for cancer. [PDF]
, 2021 INTRODUCTION Chemokines and their cognate receptors play a major role in modulating inflammatory responses. Depending on their ligand binding, chemokine receptors can stimulate both immune activating and inhibitory signaling pathways. The CC chemokine
Berger, Martin D., Hemmatazad, Hossein
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CCR5 is a receptor for Staphylococcus aureus leukotoxin ED [PDF]
Nature, 2012 Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi-component leukotoxins that are toxic towards neutrophils, but also specifically target other immune cells.
III, Francis Alonzo +8 more
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Editorial: CCR5: A receptor at the center stage in infection
Frontiers in Immunology, 2022 No abstract ...
Ellwanger, Joel Henrique +3 more
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Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 [PDF]
Nature Communications, 2021 AbstractThe chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine recognition and receptor activation remain elusive. Here we report three cryo-electron microscopy structures of Gi1 protein-coupled CCR5 in a ligand-free state and in complex with the chemokine ...
Hui Zhang +11 more
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