Results 41 to 50 of about 33,714 (244)
pH‐Independent Endocytic Cycling of the Chemokine Receptor CCR5 [PDF]
Traffic, 2004 Following agonist activation, the chemokine receptor CCR5 is internalised through clathrin‐coated pits and delivered to recycling endosomes. Subsequently, ligand‐ free and resensitised receptors are recycled to the cell surface. Currently little is known of the mechanisms regulating resensitisation and recycling of this G‐protein coupled receptor. Here
Signoret, N. +3 more
openaire +4 more sources
The role of CCR5 polymorphism in colorectal cancer and liver metastasis in the Tunisian population [PDF]
Archives of Biological Sciences, 2021 Chemokines and their receptors are involved in cancer initiation and progression, including colorectal cancer (CRC) and liver metastasis formation. Our aim was to elucidate C-C chemokine receptor type 5 (CCR5) gene polymorphism (CCR5Δ32) impact on CRC ...
Weslati Marwa +4 more
doaj +1 more source
The Iraqi Journal of Medical Sciences, 2016 Background: Tacrolimus is an immunosuppressive agent used topically, it has been found to be effective in treating moderate to severe atopic dermatitis without causing the atrophy that might occur with prolonged use of topical corticosteroids.
Nidhal AM Mohammed, Ahmad H. Muhana
doaj +6 more sources
Characterization of the CCR5 chemokine receptor gene [PDF]
Biochemistry and Molecular Biology Education, 2004 AbstractThe life cycle of retroviruses is an essential topic of modern cell biology instruction. Furthermore, the process of HIV viral entry into the cell is a question of great interest in basic and clinical biology. This paper describes how students can easily recover their own DNA, amplify a portion of the CCR5 chemokine receptor gene, characterize ...
openaire +2 more sources
Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme [PDF]
Radiology and Oncology, 2019 Abstract Background Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12 to 15 months after the diagnosis. This is mostly due to therapy resistant glioblastoma stem cells in addition to intertumour heterogeneity that is due to infiltration of a ...
Koprivnikar Krajnc, Miha +3 more
openaire +6 more sources
CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease [PDF]
, 2001 Lymph nodes with Hodgkin disease (HD) harbor few neoplastic cells in a marked leukocytic infiltrate. Since chemokines are likely to be involved in the recruitment of these leukocytes, the expression of potentially relevant chemokines and chemokine ...
Schärli, P +15 more
core +1 more source
JM4 is a four‐transmembrane protein binding to the CCR5 receptor [PDF]
FEBS Letters, 2005 The CC chemokine receptor 5 (CCR5) is a major co‐receptor for human immunodeficiency virus (HIV) and CCR5 mutants lacking the carboxy (C)‐terminus interfere with HIV infection. Therefore, we analysed the C‐terminus of CCR5 and here describe Jena‐Muenchen 4 (JM4), a novel CCR5‐interacting protein.
Schweneker M, Bachmann AS, Moelling K
openaire +3 more sources
Chemokine Receptor 5, a Double-Edged Sword in Metabolic Syndrome and Cardiovascular Disease
Frontiers in Pharmacology, 2020 The key characteristic of cardiovascular disease (CVD) is endothelial dysfunction, which is likely the consequence of inflammation. It is well demonstrated that chemokines and their receptors play a crucial role in regulating inflammatory responses, and ...
Zhongwen Zhang +14 more
doaj +1 more source
A Pocket Guide to CCR5—Neurotropic Flavivirus Edition
Viruses, 2023 CCR5 is among the most studied chemokine receptors due to its profound significance in human health and disease. The notion that CCR5 is a functionally redundant receptor was challenged through the demonstration of its unique protective role in the ...
Amit Garg, Jean K. Lim
doaj +1 more source
Schematic representation of the chemokine receptors CCR5 and CXCR4 and the chimeric CCR5/CXCR4 receptors. [PDF]
, 2013 Chimeric receptors FC-1, FC-2, FC-4b, FC-5, FC-6 and FC-7 were obtained by replacing successively larger parts of CCR5 with corresponding regions of CXCR4.
Marisa Zanchetta (309064) +8 more
core +1 more source