Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis. [PDF]
PLoS ONE, 2011 BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model ...
Maria C Lebre +8 more
doaj +1 more source
Interaction between the CCR5 chemokine receptors and microbial HSP70 [PDF]
, 2006 Evidence is presented that the microbial 70-kD heat shock protein (HSP70) binds to CCR5 chemokine receptors in CCR5-transfected cell lines and in primary human cells.
Yufei Wang +15 more
core +1 more source
HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization [PDF]
Proceedings of the National Academy of Sciences, 2000 The identification of the chemokine receptors as receptors for HIV-1 has boosted interest in these molecules, raising expectations for the development of new strategies to prevent HIV-1 infection. The discovery that chemokines block HIV-1 replication has focused attention on identifying their mechanism of action.
A J, Vila-Coro +6 more
openaire +2 more sources
Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5 [PDF]
, 2023 Inflammatory chemokines are often elevated in disease settings, where the largest group of CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors CCR1 and CCR5.
Louka, Stavroula +8 more
core +1 more source
Expression of CXCR4 or CCR5 and CCR5 mutant receptors tagged with fluorescent proteins. [PDF]
, 2013 A. The indicated CFP- or YFP-tagged receptors, transiently expressed in HEK293 cells, were detected in whole cell lysates by western blotting with an anti-GFP antibody. Untransfected HEK293 cells were included as a negative control. B.
Tian Jin (63393) +2 more
core +1 more source
Synthesis and Characterization of Fluorescent and Photoactivatable MIP-1 alpha Ligands and Interactions with Chemokine Receptors CCR1 and CCR5 [PDF]
, 2001 International audiencePhotoaffinity and fluorescent analogues of the 70-amino acid chemokine macrophage inflam-matory protein-1R (MIP-1R) were designed, synthesized, characterized, and applied to probe MIP-1R interactions with the chemokine receptors ...
CHOLLET, André +4 more
core +3 more sources
Single-molecule and super-resolved imaging deciphers membrane behavior of onco-immunogenic CCR5
iScience, 2022 Summary: The ability of tumors to establish a pro-tumorigenic microenvironment is an important point of investigation in the search for new therapeutics.
Patrick Hunter +4 more
doaj +1 more source
Fusion activity of wild type and mutant CCR5 receptors. [PDF]
, 2013 A, HOS cells stably expressing CD4 and the luciferase reporter gene were transiently transfected with wild type (▪) or mutant CCR5 receptors Thr2.56(82)Lys (•), Thr2.56(82)Pro (▴), Thr2.56(82)Lys/Arg6.32(225)Gln (○) or Thr2.56(82)Pro/Arg6.32(225)Gln (Δ).
Mei-Chi Chan (287423) +4 more
core +1 more source
Effects of chemically induced β-arrestin 1 translocation to chemokine receptors CXCR4 and CCR5 [PDF]
, 2021 Based on heterodimerization of chemokine receptors CXCR4 and CCR5 with β-arrestin 1 in co-expressing HEK 293 cells, this study shows β-arrestin 1-dependent effects without usual ligand induced receptor and G protein activation.
Vogt, Viola
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source