Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
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mBio, 2016 Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC.
Kayan Tam +8 more
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Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study. [PDF]
PLoS ONE, 2012 Chemokine receptors are G protein-coupled receptors that contain seven transmembrane domains. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple ...
Gugan Kothandan +2 more
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Expression, purification and characterization of the HIV-1 coreceptor CCR5 and its ligand RANTES and high-pressure NMR investigation of hydrogen bonds in biomolecules [PDF]
, 2010 Nuclear magnetic resonance spectroscopy is a very versatile technique for the investigation of biomolecular structures and dynamics. In this thesis, solution and solid state NMR methods have been applied to study a membrane protein and its interactions ...
Nisius, Lydia
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Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]
, 2009 Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Rossol, Manuela +6 more
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Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]
, 2010 The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P. +22 more
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Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2010 The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis.
Denise Silveira-Lemos +10 more
doaj +1 more source
Mechanisms of internalization and recycling of the chemokine receptor, CCR5 [PDF]
European Journal of Biochemistry, 2003 CCR5 is a G protein‐coupled receptor that binds several natural chemokines but it is also a coreceptor for the entry of M tropic strains of HIV‐1 into cells. Levels of CCR5 on the cell surface are important for the rate of HIV‐1 infection and are determined by a number of factors including the rates of CCR5 internalization and recycling.
Mueller, A., Strange, P. G.
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Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling [PDF]
Cellular and Molecular Neurobiology, 2020 AbstractMany G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency virus 1 (HIV-1), normally signals through the heterotrimeric G protein, Gi.
Mizuho Horioka +4 more
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Prediction of Structure, Function, and Spectroscopic Properties of G-Protein-Coupled Receptors: Methods and Applications [PDF]
, 2004 G-protein-coupled receptors are of great pharmaceutical interest, comprising the majority of targets for currently marketed drugs. The theme of my thesis is the development of the structure prediction method, MembStruk, for the superfamily of G-protein ...
Trabanino, Rene Jouvanni
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