Results 1 to 10 of about 706,384 (218)

Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]

Endocrinology and Metabolism, 2021
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
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Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

eLife, 2022
Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs.
Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia   +6 more
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Approach to map nanotopography of cell surface receptors

Communications Biology, 2022
A super-resolution localisation-based method is shown to map receptor topography in immune cells, which allows quantitative study of molecules and their interactions at the complex surface nanomorphology of cells.
Christian Franke, Tomáš Chum, Zuzana Kvíčalová, Daniela Glatzová, Gregor Jörg Gentsch, Alvaro Rodriguez, Dominic A. Helmerich, Lucas Herdly, Harsha Mavila, Otakar Frank, Tomáš Brdička, Sebastian van de Linde, Marek Cebecauer   +12 more
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Multiple Targets for Oxysterols in Their Regulation of the Immune System

Cells, 2021
Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system.
Lisa Reinmuth, Cheng-Chih Hsiao, Jörg Hamann, Mette Rosenkilde, John Mackrill   +4 more
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Protein phosphatase 2A regulation of GABAB receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection

Frontiers in Molecular Neuroscience, 2022
One major factor regulating the strength of GABAB receptor signaling and thereby neuronal excitability is the dynamic control of their cell surface expression.
Mohammad Hleihil, Mohammad Hleihil, Karthik Balakrishnan, Dietmar Benke, Dietmar Benke, Dietmar Benke   +5 more
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Research Progress on NK Cell Receptors and Their Signaling Pathways

Mediators of Inflammation, 2020
Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent
Yingying Chen, Dan Lu, Alexey Churov, Rong Fu   +3 more
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Aptamers for Targeted Drug Delivery

Pharmaceuticals, 2010
Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a ...
Partha Ray, Rebekah R. White
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Cell-surface receptors enable perception of extracellular cytokinins

Nature Communications, 2020
The main site of cytokinin perception in plant cells is thought to be the endoplasmic reticulum where most cytokinin receptors localise. Here via the use of bioactive probes that cannot enter plant cells and super-resolution microscopy, Antoniadi et al ...
Ioanna Antoniadi, Ondřej Novák, Zuzana Gelová, Alexander Johnson, Ondřej Plíhal, Radim Simerský, Václav Mik, Thomas Vain, Eduardo Mateo-Bonmatí, Michal Karady, Markéta Pernisová, Lenka Plačková, Korawit Opassathian, Jan Hejátko, Stéphanie Robert, Jiří Friml, Karel Doležal, Karin Ljung, Colin Turnbull   +18 more
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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background A hallmark of heart failure is cardiac fibrosis, which results from the injury‐induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix.
Nicholas W. Chavkin, Soichi Sano, Ying Wang, Kosei Oshima, Hayato Ogawa, Keita Horitani, Miho Sano, Susan MacLauchlan, Anders Nelson, Karishma Setia, Tanvi Vippa, Yosuke Watanabe, Jeffrey J. Saucerman, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh   +15 more
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Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
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