Results 1 to 10 of about 1,264,290 (222)
The NAE Pathway: Autobahn to the Nucleus for Cell Surface Receptors [PDF]
Cells, 2019 Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with
Poonam Shah +3 more
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Approach to map nanotopography of cell surface receptors [PDF]
Communications Biology, 2022 A super-resolution localisation-based method is shown to map receptor topography in immune cells, which allows quantitative study of molecules and their interactions at the complex surface nanomorphology of cells.
Christian Franke +12 more
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Increased accuracy of ligand sensing by receptor internalization [PDF]
Phys. Rev. E 81, 021909 (2010), 2010 Many types of cells can sense external ligand concentrations with cell-surface receptors at extremely high accuracy. Interestingly, ligand-bound receptors are often internalized, a process also known as receptor-mediated endocytosis. While internalization is involved in a vast number of important functions for the life of a cell, it was recently also ...
A. Levitzki +12 more
arxiv +3 more sources
Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF [PDF]
eLife, 2014 Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Guo Cheng +7 more
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Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy [PDF]
Cancer Cell International, 2022 Background Immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized cancer therapy. However, therapeutic targeting of inhibitory T cell receptors such as PD-1 not only initiates a broad immune response against tumors, but also causes ...
Simon Heumos +7 more
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Cell-surface receptors enable perception of extracellular cytokinins [PDF]
Nature Communications, 2020 The main site of cytokinin perception in plant cells is thought to be the endoplasmic reticulum where most cytokinin receptors localise. Here via the use of bioactive probes that cannot enter plant cells and super-resolution microscopy, Antoniadi et al ...
Ioanna Antoniadi +18 more
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Synthetic transmembrane DNA receptors enable engineered sensing and actuation [PDF]
Nature CommunicationsIn living organisms, cells synergistically couple cascade reaction pathways to achieve inter- and intracellular signal transduction by transmembrane protein receptors.
Ze-Rui Zhou +7 more
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Cell Surface Receptors in the 21st Century
AIMS Biophysics, 2014 Andrew H.A. Clayton
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]
Endocrinology and Metabolism, 2021 Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
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eLife, 2022 Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs.
Dirk H Siepe +6 more
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