Results 1 to 10 of about 636,621 (274)

Approach to map nanotopography of cell surface receptors [PDF]

Communications Biology, 2022
AbstractCells communicate with their environment via surface receptors, but nanoscopic receptor organization with respect to complex cell surface morphology remains unclear. This is mainly due to a lack of accessible, robust and high-resolution methods.
Christian Franke, Tomáš Chum, Zuzana Kvíčalová, Daniela Glatzová, Gregor Jörg Gentsch, Alvaro Rodriguez, Dominic A. Helmerich, Lucas Herdly, Harsha Mavila, Otakar Frank, Tomáš Brdička, Sebastian van de Linde, Marek Cebecauer   +12 more
openaire   +5 more sources

Increased accuracy of ligand sensing by receptor internalization [PDF]

Phys. Rev. E 81, 021909 (2010), 2010
Many types of cells can sense external ligand concentrations with cell-surface receptors at extremely high accuracy. Interestingly, ligand-bound receptors are often internalized, a process also known as receptor-mediated endocytosis. While internalization is involved in a vast number of important functions for the life of a cell, it was recently also ...
A. Levitzki, D. D. Jenness, F. Kesbeke, Gerardo Aquino, H. C. Berg, J. E. Segall, K. A. Schandel, L. Opresko, R. C. Roberts, Robert G. Endres, S. K. Raths, S. Mukherjee, S. S. F. Ferguson   +12 more
arxiv   +3 more sources

The NAE Pathway : autobahn to the nucleus for cell surface receptors [PDF]

Cells, 2019
Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with
Bard, Frederic A., Chaumet, Alexandre, Royle, Stephen J., Shah, Poonam   +3 more
core   +3 more sources

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. [PDF]

eLife, 2014
Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Al-Ubaidi, Muayyad, Cheng, Guo, Deng, Jun, Kassai, Miki, Kawaguchi, Riki, Sun, Hui, Ter-Stepanian, Mariam, Zhong, Ming   +7 more
core   +3 more sources

Optimal receptor-cluster size determined by intrinsic and extrinsic noise [PDF]

Phys. Rev. E 83, 021914, (2011), 2011
Biological cells sense external chemical stimuli in their environment using cell-surface receptors. To increase the sensitivity of sensing, receptors often cluster, most noticeably in bacterial chemotaxis, a paradigm for signaling and sensing in general.
Diana Clausznitzer, Gerardo Aquino, J. M. Brass, M. A. Hediger, N. G. van Kampen, Robert G. Endres, Sylvain Tollis   +6 more
arxiv   +3 more sources

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

Cell surface receptors

Current Opinion in Structural Biology, 2000
During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new models for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for ...
Deller, M, Yvonne Jones, E
openaire   +4 more sources

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly [PDF]

, 2010
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters.
A Radu Aricescu, AG Leslie, AJ McCoy, AR Aricescu, BC Cunningham, C Litterst, CD Thanos, CJ Vearing, CN Chin, D Nikolov, DP Zelinski, E Yvonne Jones, EB Pasquale, EB Pasquale, Elena Seiradake, Eph Nomenclature Committee, EV Bocharov, F Grueninger-Leitch, FM Smith, G Shaw, Geoff Sutton, H Miao, IW Davis, J Egea, J Wykosky, JD Bendtsen, JE Chrencik, JP Himanen, JP Himanen, JP Himanen, JP Himanen, JP Himanen, K Diedrichs, K Miura, Karl Harlos, KT Lin, M Landau, MA Cooper, MS Kinch, N Carter, ND Zantek, NW Gale, P Emsley, P Gouet, PD Adams, PJ Reeves, RA Lindberg, RF Carvalho, S Davis, S Orsulic, SH Wimmer-Kleikamp, T Nagai, TA Bowden, TS Walter, TS Walter, VT Chang, W Kabsch, YG Lin   +57 more
core   +1 more source

Direct visualization of superselective colloid-surface binding mediated by multivalent interactions [PDF]

, 2021
Reliably distinguishing between cells based on minute differences in receptor density is crucial for cell-cell or virus-cell recognition, the initiation of signal transduction and selective targeting in directed drug delivery. Such sharp differentiation between different surfaces based on their receptor density can only be achieved by multivalent ...
arxiv   +1 more source