Results 1 to 10 of about 459,582 (109)
The NAE Pathway: Autobahn to the Nucleus for Cell Surface Receptors [PDF]
Cells, 2019 Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with
Poonam Shah +3 more
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Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF [PDF]
eLife, 2014 Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Guo Cheng +7 more
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]
Endocrinology and Metabolism, 2021 Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
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eLife, 2022 Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs.
Dirk H Siepe +6 more
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Approach to map nanotopography of cell surface receptors
Communications Biology, 2022 A super-resolution localisation-based method is shown to map receptor topography in immune cells, which allows quantitative study of molecules and their interactions at the complex surface nanomorphology of cells.
Christian Franke +12 more
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Multiple Targets for Oxysterols in Their Regulation of the Immune System
Cells, 2021 Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system.
Lisa Reinmuth +4 more
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Research Progress on NK Cell Receptors and Their Signaling Pathways
Mediators of Inflammation, 2020 Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent
Yingying Chen +3 more
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Frontiers in Molecular Neuroscience, 2022 One major factor regulating the strength of GABAB receptor signaling and thereby neuronal excitability is the dynamic control of their cell surface expression.
Mohammad Hleihil +5 more
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An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly [PDF]
, 2010 Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters.
A Radu Aricescu +57 more
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Aptamers for Targeted Drug Delivery
Pharmaceuticals, 2010 Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a ...
Partha Ray, Rebekah R. White
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