The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling. [PDF]
PLoS ONE, 2017 Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL) associates with mutational IGHV status and favourable prognosis.
Inna Gordiienko +6 more
doaj +1 more source
Particle compositions with a pre-selected cell internalization mode [PDF]
, 2012 A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of ...
Decuzzi, Paolo, Ferrari, Mauro
core +1 more source
The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]
, 2014 G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin +8 more
core +2 more sources
Evolutionary trajectory of pattern recognition receptors in plants
Nature CommunicationsCell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive.
Bruno Pok Man Ngou +4 more
doaj +1 more source
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
PLoS Computational BiologyThe vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and co-receptors such as Neuropilin (NRP) expressed on endothelial cells. These
Sarvenaz Sarabipour +6 more
doaj +1 more source
eLife, 2015 Cell surface receptors are central to the cell's ability to generate coordinated responses to the multitude of biochemical and physical cues in the microenvironment.
Joanna P Rys +8 more
doaj +1 more source
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. [PDF]
PLoS Biology, 2009 G-protein-coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become internalized upon repeated or prolonged stimulation.
Davide Calebiro +7 more
doaj +1 more source
Natural killer cells as an initial defense against pathogens. [PDF]
, 2006 Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
core
The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells [PDF]
, 2009 The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in many cancer cells. However, a significant proportion of tumours are TRAIL-resistant erecting a major hurdle for a successful TRAIL-based treatment ...
Zwacka,
core +1 more source
Syndecans: multifunctional cell-surface co-receptors [PDF]
Biochemical Journal, 1997 This review will summarize our current state of knowledge of the structure, biochemical properties and functions of syndecans, a family of transmembrane heparan sulphate proteoglycans. Syndecans bind a variety of extracellular ligands via their covalently attached heparan sulphate chains.
openaire +2 more sources