Results 131 to 140 of about 437,706 (248)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.

PLoS Biology
Development of optimal therapeutics for disease states that can be associated with increased membrane cholesterol requires better molecular understanding of lipid modulation of the drug target.
Kaleeckal G Harikumar, Peishen Zhao, Brian P Cary, Xiaomeng Xu, Aditya J Desai, Maoqing Dong, Jesse I Mobbs, Chirine Toufaily, Sebastian G B Furness, Arthur Christopoulos, Matthew J Belousoff, Denise Wootten, Patrick M Sexton, Laurence J Miller   +13 more
doaj   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

Dialectics of perisomatic inhibition—The unity and conflict of opposites

Frontiers in Neural Circuits
Over the past three decades, a great deal of attention has been paid to the study of perisomatic inhibition and perisomatic inhibitory basket cells. A growing body of experimental evidence points to the leading role of perisomatic inhibitory cells in the
Andrei Rozov, Andrei Rozov, Andrei Rozov, David John Jappy, David John Jappy, Ksenia Maltseva, Alina Vazetdinova, Alina Vazetdinova, Fliza Valiullina-Rakhmatullina, Fliza Valiullina-Rakhmatullina   +9 more
doaj   +1 more source

Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira, ZhiDi Deng, Manfred J. Muller, Giovanna G. L. Bergamasco, Sarah Cawsey, Melania Manco, Steven B. Heymsfield, Carla M. Prado, Andrea M. Haqq   +8 more
wiley   +1 more source

Functional evidence for the involvement of GABA(A) receptors in cholecystokinin induced ileal contraction [PDF]

, 1995
To determine the role of GABAergic neurotransmission in cholecystokinin octapeptide (CCK-8) induced contraction of the guinea pig ileal longitudinal muscle - myenteric plexus preparation, CCKA or CCKB receptors were protected by L 364,718 and L 365,260 ...

core  

Peripheral CCK-A and CCK-B receptors mediate stimulation of gastric pepsinogen and acid secretion following intracerebroventricular injection of cholecystokinin-8-sulfate [PDF]

, 1999
BACKGROUND: Peptides of cholecystokinin family regulate various physiological actions by acting at level of central nervous system. AIMS: To: 1) investigate possible influence of central cholecystokinin pathways on gastric pepsinogen and acid ...
CARIGNANI D., COLUCCI R., LAZZERI, GLORIA, BASCHIERA F., TOGNETTI M., BLANDIZZI, CORRADO, PLACANICA, GIORGIO, DEL TACCA, MARIO   +7 more
core   +2 more sources

Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut

Physiological Reports
The gut microbiome (GMB) regulates digestion, metabolism, immunity, and energy homeostasis. This study investigates how gut microbiota integrate the regulation in the neuroendocrine and enteroendocrine systems, with a focus on G protein‐coupled receptors
Wynne Milhouse, Anna Clapp Organski, Xun Sun, Derek Ai, Baohua Zhou, Tzu‐Wen L. Cross, Hongxia Ren   +6 more
doaj   +1 more source

Ingestão de água e alimento após o bloqueio de receptores glutamatérgicos ionotrópicos no arcopalio intermédio, região lateral do núcleo interstical da estria terminal e núcleo taeniae da amígdala de pombos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Neurociências, Florianópolis, 2010O presente trabalho examinou os efeitos da microinjeção de MK-801 (antagonista de receptor NMDA), nas
Silva, Amanda Alcaraz da
core  

Progress of Researches on Central Mechanism of Electroacupuncture Tolerance

针刺研究, 2016
Electroacupuncture(EA)has been demonstrated effective for pain relief.However,repeated application may decline analgesic effect of EA,which is termed EA tolerance,that reduces the clinical efficacy of EA.Therefore,it has attracted attention from ...
CUI Lu-ying, DING Ming-xing
doaj