Results 11 to 20 of about 30,055 (235)

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

Frontiers in Endocrinology, 2021
Cholecystokinin is a gastrointestinal peptide hormone with important roles in metabolic physiology and the maintenance of normal nutritional status, as well as potential roles in the prevention and management of obesity, currently one of the dominant ...
Laurence J. Miller, Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton   +3 more
doaj   +1 more source

Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes

Frontiers in Physiology, 2023
Aims: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs).
Hongmei Ruan, Ravi Mandla, Namita Ravi, Giselle Galang, Amanda W. Soe, Jeffrey E. Olgin, Di Lang, Vasanth Vedantham   +7 more
doaj   +1 more source

Structural insights into human brain–gut peptide cholecystokinin receptors

Cell Discovery, 2022
The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory regulation.
Yu Ding, Huibing Zhang, Yu-Ying Liao, Li-Nan Chen, Su-Yu Ji, Jiao Qin, Chunyou Mao, Dan-Dan Shen, Lin Lin, Hao Wang, Yan Zhang, Xiao-Ming Li   +11 more
doaj   +1 more source

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium [PDF]

, 2013
Several deleterious intra-acinar phenomena are simultaneously triggered on initiating acute pancreatitis. These culminate in acinar injury or inflammatory mediator generation in vitro and parenchymal damage in vivo. Supraphysiologic caerulein is one such
A Gnoni, A Pace, A Sharma, AJ Hietaranta, AK Saluja, AK Saluja, AS Gukovskaya, B Han, B Han, B Hofbauer, B Kruger, C Schafer, Catherine J. Baty, CH Kubisch, Chandra Durgampudi, Chathur Acharya, DN Criddle, Donna B. Stolz, EC Thrower, EM Parker, F Gorelick, F Mooren, F Nozu, G Lynch, H Weber, HK Baumgartner, I Gukovsky, I Gukovsky, I Samuel, JA Tapia, JA Williams, Jenny Karlsson, JV Gerasimenko, KA Muili, Krutika Patel, L Fischer, L Orlichenko, Lidiya Orlichenko, LJ Christopher, LJ Lombardo, LS Orlichenko, M Sendler, MS O'Konski, OA Mareninova, OH Petersen, Pawan Noel, PC Redondo, Rachel Cline, Ram Narayan Trivedi, RD Duan, RR Torgerson, RR Torgerson, S Kawabata, S Navina, Sarah Navina, SD Waterford, SG Weller, SJ Pandol, Sohail Z. Husain, Stuart E. Dryer, SZ Husain, SZ Husain, T Eley, T Grady, T Grady, V Sancho, Vijay P. Singh, Vivek Mishra, VP Singh, VP Singh, VP Singh, VP Singh, Y Tsunoda   +72 more
core   +5 more sources

Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. [PDF]

PLoS ONE, 2015
Cholecystokinin (CCK), a peptide hormone and one of the most abundant neuropeptides in vertebrate brain, mediates its actions via two G-protein coupled receptors, CCKAR and CCKBR, respectively active in peripheral organs and the central nervous system ...
Sayoko Nishimura, Kaya Bilgüvar, Keiko Ishigame, Nenad Sestan, Murat Günel, Angeliki Louvi   +5 more
doaj   +1 more source

Roles of interleukin-9 in the growth and cholecystokinin-induced intracellular calcium signaling of cultured interstitial cells of Cajal. [PDF]

PLoS ONE, 2014
Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal (GI) tract and loss of ICC is associated with many GI motility disorders.
Yaoyao Gong, Lei Huang, Wenfang Cheng, Xueliang Li, Jia Lu, Lin Lin, Xinmin Si   +6 more
doaj   +1 more source

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

eLife, 2021
Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias ...
Ana B Tinoco, Antón Barreiro-Iglesias, Luis Alfonso Yañez Guerra, Jérôme Delroisse, Ya Zhang, Elizabeth F Gunner, Cleidiane G Zampronio, Alexandra M Jones, Michaela Egertová, Maurice R Elphick   +9 more
doaj   +1 more source

Signaling properties and pharmacological analysis of two sulfakinin receptors from the red flour beetle, Tribolium castaneum. [PDF]

PLoS ONE, 2014
Sulfakinin is an insect neuropeptide that constitutes an important component of the complex network of hormonal and neural factors that regulate feeding and digestion. The key modulating functions of sulfakinin are mediated by binding and signaling via G-
Sven Zels, Heleen Verlinden, Senne Dillen, Rut Vleugels, Ronald J Nachman, Jozef Vanden Broeck   +5 more
doaj   +1 more source

Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors. [PDF]

PLoS ONE, 2012
Enteroendocrine cells have a critical role in regulation of appetite and energy balance. I-cells are a subtype of enteroendocrine cells localized in duodenum that release cholecystokinin in response to ingested fat and amino-acids.
Alexandros G Sykaras, Claire Demenis, R Maynard Case, John T McLaughlin, Craig P Smith   +4 more
doaj   +1 more source

Intestinal microbiome dysbiosis in alcohol-dependent patients and its effect on rat behaviors

mBio, 2023
Alcohol dependence (AD) is a worldwide epidemic of psychiatric disorders. Gut microbiota dysbiosis may be involved in the development of AD. Recently, the number of studies on the relationship between gut microbiota and alcohol is increasing.
Chuansheng Wang, Junli Yan, Keda Du, Shuai Liu, Jiali Wang, Qi Wang, Huajie Zhao, Min Li, Dong Yan, Ruiling Zhang, Fan Yang   +10 more
doaj   +1 more source