Results 41 to 50 of about 16,169 (200)

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Cholecystokinin: an excitatory modulator of mitral/tufted cells in the mouse olfactory bulb. [PDF]

PLoS ONE, 2013
Cholecystokinin (CCK) is widely distributed in the brain as a sulfated octapeptide (CCK-8S). In the olfactory bulb, CCK-8S is concentrated in two laminae: an infraglomerular band in the external plexiform layer, and an inframitral band in the internal ...
Jie Ma, Luba Dankulich-Nagrudny, Graeme Lowe   +2 more
doaj   +1 more source

Drosulfakinin signaling modulates female sexual receptivity in Drosophila

eLife, 2022
Female sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood.
Tao Wang, Biyang Jing, Bowen Deng, Kai Shi, Jing Li, Baoxu Ma, Fengming Wu, Chuan Zhou   +7 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Visceral pain-related acute actions of cerulein on mouse and human sensory neurons

Molecular Pain
Cerulein is an orthologue of cholecystokinin, which is often used to induce acute pancreatitis in pre-clinical studies. In these models, animals show signs of pain, and this is the most common complaint of patients with acute pancreatitis.
Sachin Goyal, Nesia Zurek, Reza Ehsanian, Shivali Goyal, David T Jones, Mark Shilling, Gary V Desir, Fred Gorelick, Karin N Westlund, Sascha RA Alles   +9 more
doaj   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

GABABR-dependent Long-Term Depression at Hippocampal Synapses Between CB1-positive Interneurons and CA1 Pyramidal Cells

Frontiers in Cellular Neuroscience, 2016
Activity induced long lasting modifications of synaptic efficacy have been extensively studied in excitatory synapses, however long term plasticity is also a property of inhibitory synapses.
Dave eJappy, Fliza eValiullina, Andreas eDraguhn, Andrei eRozov, Andrei eRozov   +4 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Sensing of luminal contents and downstream modulation of GI function

JGH Open
The luminal environment is rich in macronutrients coming from our diet and resident microbial populations including their metabolites. Together, they have the capacity to modulate unique cell surface receptors, known as G‐protein coupled receptors (GPCRs)
Kiran Devi Dontamsetti, Laura Camila Pedrosa‐Suarez, Rubina Aktar, Madusha Peiris   +3 more
doaj   +1 more source

Postprandial Glycemic Control With Automated Insulin Delivery With Control‐IQ Technology: The Impact of Meal Composition

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the efficiency of the AID system with Control‐IQ technology and carbohydrate counting (CHC)–based premeal bolus to control postprandial glucose (PPG) after mixed meals with different macronutrient compositions in adolescents with type 1 diabetes (T1D).
Marco Marigliano, Claudia Piona, Elisa Morotti, Maddalena Macedoni, Parto Kharazizadeh, Valentina Mancioppi, Francesca Tomasselli, Mara Tommasi, Claudio Maffeis   +8 more
wiley   +1 more source