Results 21 to 30 of about 16,141 (203)

Blockade of Cholecystokinin Type 2 Receptors Prevents the Onset of Vincristine-Induced Neuropathy in Mice

Pharmaceutics, 2022
Vincristine (VCR) is responsible for the onset of the VCR-induced peripheral neuropathy (VIPN), associated with neuropathic pain. Several reports have strongly linked the cholecystokinin type 2 receptor (CCK2R) to nociceptive modulation.
Amandine Bernard, Aurore Danigo, Mohamad Mroué, Amandine Rovini, Laurence Richard, Angélique Nizou, Alexis Desmoulière, Franck Sturtz, Claire Demiot, Sylvie Bourthoumieu   +9 more
doaj   +1 more source

G-protein-coupled receptors and islet function-Implications for treatment of type 2 diabetes. [PDF]

, 2007
Islet function is regulated by a number of different signals. A main signal is generated by glucose, which stimulates insulin secretion and inhibits glucagon secretion.
Sörhede Winzell, Maria, Ahrén, Bo
core   +1 more source

Expression of CCK Receptors in Carcinoma Gallbladder and Cholelithiasis: A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Gastrin and cholecystokinin (CCK) receptors are trophic for various gastrointestinal malignancies. Their role in gallbladder cancer has not been widely studied. Objectives: To identify expression of CCK-A and CCK-B receptors in the tissue
Mohammad Shazib Faridi, Mahabir Saran Das Jaiswal, Sudhir K. Goel   +2 more
doaj   +1 more source

Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells

International Journal of Endocrinology, 2009
With the exclusive presence of the pancreatic CCK-2 receptors on the pancreatic delta cells of six different species, this study was undertaken to determine the role of cholecystokinin and gastrin on growth of these somatostatin (SS) cells.
Karim El-Kouhen, Jean Morisset
doaj   +1 more source

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.

PLoS Biology, 2021
G protein-coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing
Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton   +12 more
doaj   +1 more source

Dietary phosphorus level regulates appetite through modulation of gut and hypothalamic expression of anorexigenic genes in broiler chickens

Poultry Science, 2022
: Two experiments were designed to elucidate gut and hypothalamic molecular regulation of appetite by dietary phosphorus (P) concentration in broiler chickens.
A.S. Aderibigbe, K.M. Ajuwon, O. Adeola
doaj   +1 more source

Heterogeneity of cholecystokinin receptors in pancreas

Biochemical and Biophysical Research Communications, 1987
Specific labeling of a major Mr 85-95 K protein was obtained using the SH, NH2 heterobifunctional cross-linker m-maleimidobenzoyl N-hydroxysuccinimide ester (MBS) to affinity label cholecystokinin (CCK) receptors on rat pancreatic plasma membranes, pancreatic acinar cells and acinar cell tumor membranes with 125I-CCK-33.
L D, Madison, J D, Jamieson, S A, Rosenzweig   +2 more
openaire   +2 more sources

Putative chemosensory receptors are differentially expressed in the sensory organs of male and female crown-of-thorns starfish, Acanthaster planci

BMC Genomics, 2018
Background Chemosensation is a critical signalling process for all organisms and is achieved through the interaction between chemosensory receptors and their ligands.
R. E. Roberts, D. Powell, T. Wang, M. H. Hall, C. A. Motti, S. F. Cummins   +5 more
doaj   +1 more source

Neuroendocrine and Molecular Interactions in Eating Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2014
There are three basic pillars for the development of eating disorders: genetic predisposition, neuro-endocrine-molecular changes in the brain and metabolic response to it.
Selma Bozkurt Zincir
doaj   +1 more source

BRAIN CHOLECYSTOKININ SYSTEM IN NEUROTIC PATHOLOGY

Проблеми екології та медицини, 2023
Violation and discoordination of mental processes leads to changes in the ratio of the main neurotransmitters content and further to mental disorders. A significant role in such processes is played by neuropeptides, in particular anti-anxiety ones, which
R.V. Lutsenko, A.V. Vakhnenko, G.Yu. Ostrovska, N.V. Moiseieva, O.A. Lutsenko   +4 more
doaj   +1 more source