Results 21 to 30 of about 16,169 (200)

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.

PLoS Biology, 2021
G protein-coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing
Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton   +12 more
doaj   +1 more source

Putative chemosensory receptors are differentially expressed in the sensory organs of male and female crown-of-thorns starfish, Acanthaster planci

BMC Genomics, 2018
Background Chemosensation is a critical signalling process for all organisms and is achieved through the interaction between chemosensory receptors and their ligands.
R. E. Roberts, D. Powell, T. Wang, M. H. Hall, C. A. Motti, S. F. Cummins   +5 more
doaj   +1 more source

Neuroendocrine and Molecular Interactions in Eating Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2014
There are three basic pillars for the development of eating disorders: genetic predisposition, neuro-endocrine-molecular changes in the brain and metabolic response to it.
Selma Bozkurt Zincir
doaj   +1 more source

Dietary phosphorus level regulates appetite through modulation of gut and hypothalamic expression of anorexigenic genes in broiler chickens

Poultry Science, 2022
: Two experiments were designed to elucidate gut and hypothalamic molecular regulation of appetite by dietary phosphorus (P) concentration in broiler chickens.
A.S. Aderibigbe, K.M. Ajuwon, O. Adeola
doaj   +1 more source

Heterogeneity of cholecystokinin receptors in pancreas

Biochemical and Biophysical Research Communications, 1987
Specific labeling of a major Mr 85-95 K protein was obtained using the SH, NH2 heterobifunctional cross-linker m-maleimidobenzoyl N-hydroxysuccinimide ester (MBS) to affinity label cholecystokinin (CCK) receptors on rat pancreatic plasma membranes, pancreatic acinar cells and acinar cell tumor membranes with 125I-CCK-33.
L D, Madison, J D, Jamieson, S A, Rosenzweig   +2 more
openaire   +2 more sources

BRAIN CHOLECYSTOKININ SYSTEM IN NEUROTIC PATHOLOGY

Проблеми екології та медицини, 2023
Violation and discoordination of mental processes leads to changes in the ratio of the main neurotransmitters content and further to mental disorders. A significant role in such processes is played by neuropeptides, in particular anti-anxiety ones, which
R.V. Lutsenko, A.V. Vakhnenko, G.Yu. Ostrovska, N.V. Moiseieva, O.A. Lutsenko   +4 more
doaj   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Gastrin Exerts Pleiotropic Effects on Human Melanoma Cell Biology

Neoplasia: An International Journal for Oncology Research, 2005
The effects of gastrin (G17) on the growth and migration factors of four human melanoma cell lines (HT-144, C32, G-361, and SKMEL-28) were investigated. The expression patterns of cholecystokinin (CCK)A CCKB, and CCKC gastrin receptors were investigated ...
Véronique Mathieu, Tatjana Mijatovic, Marc van Damme, Robert Kiss   +3 more
doaj   +1 more source

Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion. [PDF]

PLoS Pathogens, 2013
Gastrointestinal infection is often associated with hypophagia and weight loss; however, the precise mechanisms governing these responses remain poorly defined.
John J Worthington, Linda C Samuelson, Richard K Grencis, John T McLaughlin   +3 more
doaj   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source