Results 11 to 20 of about 16,141 (203)

Intestinal microbiome dysbiosis in alcohol-dependent patients and its effect on rat behaviors

mBio, 2023
Alcohol dependence (AD) is a worldwide epidemic of psychiatric disorders. Gut microbiota dysbiosis may be involved in the development of AD. Recently, the number of studies on the relationship between gut microbiota and alcohol is increasing.
Chuansheng Wang, Junli Yan, Keda Du, Shuai Liu, Jiali Wang, Qi Wang, Huajie Zhao, Min Li, Dong Yan, Ruiling Zhang, Fan Yang   +10 more
doaj   +1 more source

First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract

Scientific Reports, 2021
This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo, Ayelén M. Blanco, Sara Comesaña, Marta Conde-Sieira, Sofia Morais, José L. Soengas   +5 more
doaj   +1 more source

Evolution of a potential hormone antagonist following gene splicing during primate evolution. [PDF]

PLoS ONE, 2013
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional proteins. Cholecystokinin (CCK) induces the release of pancreatic enzymes and the contraction of the gallbladder to promote the digestion of fat and proteins.
Cheng Deng, Aaron J W Hsueh
doaj   +1 more source

Molecular Models for Cholecystokinin‐A Receptor [PDF]

Pharmacology & Toxicology, 2002
Abstract: Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)‐related peptides with their hormone‐binding receptor, the CCK‐A receptor (CCK‐AR), including structure‐activity relationship studies, site‐directed mutagenesis, photoaffinity‐labeling, and solution NMR analysis of both CCK peptide ...
Eric S, Dawson, Randel M, Henne, Laurence J, Miller, Terry P, Lybrand   +3 more
openaire   +2 more sources

Sensitivity of cholecystokinin receptors to membrane cholesterol content

Frontiers in Endocrinology, 2012
Cholesterol represents a structurally and functionally important component of the eukaryotic cell membrane, where it increases lipid order, affects permeability, and influences the lateral mobility and conformation of membrane proteins.
Aditya J Desai, Laurence J Miller
doaj   +1 more source

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Journal of Lipid Research, 2012
Recent studies indicate that membrane cholesterol can associate with G protein-coupled receptors (GPCRs) and affect their function. Previously, we reported that manipulation of membrane cholesterol affects ligand binding and signal transduction of the ...
Ross M. Potter, Kaleeckal G. Harikumar, S.Vincent Wu, Laurence J. Miller   +3 more
doaj   +1 more source

Cholecystokinin (CCK) and its receptors (CCK1R and CCK2R) in chickens: functional analysis and tissue expression

Poultry Science, 2023
: Cholecystokinin (CCK) is widely distributed in the gastrointestinal tract and central nervous system, regulating a range of physiological functions by activating its receptors (CCK1R and CCK2R).
Yiping Wan, Qiuyang Deng, Zhichun Zhou, Yue Deng, Jiannan Zhang, Juan Li, Yajun Wang   +6 more
doaj   +1 more source

The peripheral cholecystokinin receptors

European Journal of Biochemistry, 1993
Cholecystokinin (CCK), one of the first discovered gastrointestinal hormones [1, 2] was originally isolated from the porcine duodenum as a 33-amino-acid peptide (CCK-33) [3–5]. The sequencing of CCK-33 in 1968 revealed that the peptide is structurally related to gastrin, another gut hormone characterized four years earlier [6]. Indeed, the two peptides
Silvente-Poirot, Sandrine, Dufresne, Marlène, Vaysse, Nicole, Fourmy, Daniel   +3 more
openaire   +2 more sources

Purification of the pancreatic cholecystokinin receptor [PDF]

Regulatory Peptides, 1989
We have previously shown that the pancreatic cholecystokinin (CCK) receptor can be solubilized in 1% digitonin. In this study, digitonin-solubilized CCK receptors from rat pancreas were purified using sequential affinity chromatography on ricin-II agarose and on AffiGel-CCK. Electrophoresis of the radioiodinated purified receptors on SDS-polyacrylamide
Szecowka, J., Hallden, G., Goldfine, I. D., Williams, John A.   +3 more
openaire   +3 more sources

Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate [PDF]

, 2000
Hormones and neurotransmitters mobilize Ca2+ from the endoplasmic reticulum via inositol trisphosphate (IP3) receptors, but how a single target cell encodes different extracellular signals to generate specific cytosolic Ca2+ responses is unknown.
Tepikin, Alexei V., Petersen, Ole Holger, Cansela, Jose Manuel, Gerasimenko, Julia Vladimirovna, Gerasimenko, Oleg Vsevolodovich   +4 more
core   +1 more source