Results 11 to 20 of about 30,225 (238)

First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract

Scientific Reports, 2021
This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo, Ayelén M. Blanco, Sara Comesaña, Marta Conde-Sieira, Sofia Morais, José L. Soengas   +5 more
doaj   +1 more source

Evolution of a potential hormone antagonist following gene splicing during primate evolution. [PDF]

PLoS ONE, 2013
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional proteins. Cholecystokinin (CCK) induces the release of pancreatic enzymes and the contraction of the gallbladder to promote the digestion of fat and proteins.
Cheng Deng, Aaron J W Hsueh
doaj   +1 more source

Sensitivity of cholecystokinin receptors to membrane cholesterol content

Frontiers in Endocrinology, 2012
Cholesterol represents a structurally and functionally important component of the eukaryotic cell membrane, where it increases lipid order, affects permeability, and influences the lateral mobility and conformation of membrane proteins.
Aditya J Desai, Laurence J Miller
doaj   +1 more source

Molecular Models for Cholecystokinin‐A Receptor [PDF]

Pharmacology & Toxicology, 2002
Abstract: Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)‐related peptides with their hormone‐binding receptor, the CCK‐A receptor (CCK‐AR), including structure‐activity relationship studies, site‐directed mutagenesis, photoaffinity‐labeling, and solution NMR analysis of both CCK peptide ...
Eric S, Dawson, Randel M, Henne, Laurence J, Miller, Terry P, Lybrand   +3 more
openaire   +2 more sources

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Journal of Lipid Research, 2012
Recent studies indicate that membrane cholesterol can associate with G protein-coupled receptors (GPCRs) and affect their function. Previously, we reported that manipulation of membrane cholesterol affects ligand binding and signal transduction of the ...
Ross M. Potter, Kaleeckal G. Harikumar, S.Vincent Wu, Laurence J. Miller   +3 more
doaj   +1 more source

Cholecystokinin (CCK) and its receptors (CCK1R and CCK2R) in chickens: functional analysis and tissue expression

Poultry Science, 2023
: Cholecystokinin (CCK) is widely distributed in the gastrointestinal tract and central nervous system, regulating a range of physiological functions by activating its receptors (CCK1R and CCK2R).
Yiping Wan, Qiuyang Deng, Zhichun Zhou, Yue Deng, Jiannan Zhang, Juan Li, Yajun Wang   +6 more
doaj   +1 more source

The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates [PDF]

, 2014
Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (
Elphick, MR, Mirabeau, O
core   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

The peripheral cholecystokinin receptors

European Journal of Biochemistry, 1993
Cholecystokinin (CCK), one of the first discovered gastrointestinal hormones [1, 2] was originally isolated from the porcine duodenum as a 33-amino-acid peptide (CCK-33) [3–5]. The sequencing of CCK-33 in 1968 revealed that the peptide is structurally related to gastrin, another gut hormone characterized four years earlier [6]. Indeed, the two peptides
Silvente-Poirot, Sandrine, Dufresne, Marlène, Vaysse, Nicole, Fourmy, Daniel   +3 more
openaire   +2 more sources

Purification of the pancreatic cholecystokinin receptor [PDF]

Regulatory Peptides, 1989
We have previously shown that the pancreatic cholecystokinin (CCK) receptor can be solubilized in 1% digitonin. In this study, digitonin-solubilized CCK receptors from rat pancreas were purified using sequential affinity chromatography on ricin-II agarose and on AffiGel-CCK. Electrophoresis of the radioiodinated purified receptors on SDS-polyacrylamide
Szecowka, J., Hallden, G., Goldfine, I. D., Williams, John A.   +3 more
openaire   +3 more sources