Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]
, 2020 Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn +7 more
core +1 more source
First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract
Scientific Reports, 2021 This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo +5 more
doaj +1 more source
Evolution of a potential hormone antagonist following gene splicing during primate evolution. [PDF]
PLoS ONE, 2013 Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional proteins. Cholecystokinin (CCK) induces the release of pancreatic enzymes and the contraction of the gallbladder to promote the digestion of fat and proteins.
Cheng Deng, Aaron J W Hsueh
doaj +1 more source
Sensitivity of cholecystokinin receptors to membrane cholesterol content
Frontiers in Endocrinology, 2012 Cholesterol represents a structurally and functionally important component of the eukaryotic cell membrane, where it increases lipid order, affects permeability, and influences the lateral mobility and conformation of membrane proteins.
Aditya J Desai, Laurence J Miller
doaj +1 more source
Is fat the sixth taste primary? Evidence and implications [PDF]
, 2015 Explores our tongue\u27s ability to detect fat as a distinct taste similar to our ability to sense sweet, sour, bitter, acid and savory. Abstract Taste is the chemical sense responsible for the detection of non-volatile chemicals in potential foods. For
Andrew Costanzo, Russell Keast
core +1 more source
Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]
, 2015 The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana +4 more
core +5 more sources
Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol
Journal of Lipid Research, 2012 Recent studies indicate that membrane cholesterol can associate with G protein-coupled receptors (GPCRs) and affect their function. Previously, we reported that manipulation of membrane cholesterol affects ligand binding and signal transduction of the ...
Ross M. Potter +3 more
doaj +1 more source
Poultry Science, 2023 : Cholecystokinin (CCK) is widely distributed in the gastrointestinal tract and central nervous system, regulating a range of physiological functions by activating its receptors (CCK1R and CCK2R).
Yiping Wan +6 more
doaj +1 more source
Protective effects of urocortin 2 against caerulein-induced acute pancreatitis. [PDF]
, 2019 Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) model in rats. Male
Bhargava, Aditi +6 more
core +1 more source
Pancreatic exocrine insufficiency after bariatric surgery [PDF]
, 2017 Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban +7 more
core +1 more source