Results 171 to 180 of about 79,884 (218)

Editorial: Mechanisms of cholinergic transmission in motivation and cognition. [PDF]

Front Mol Neurosci
Francis TC, Klawonn AM.
europepmc   +1 more source

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, EarlyView.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders. [PDF]

Cell Mol Neurobiol
Abraham SM, Suresh S, Komal P.
europepmc   +1 more source

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, EarlyView.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

Organophosphate Chemical Nerve Agents, Oxidative Stress, and NADPH Oxidase Inhibitors: An Overview. [PDF]

Int J Mol Sci
Meyer C, Thippeswamy T.
europepmc   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets. [PDF]

Mol Cancer
Zhang C, Guo X, Wang Y, Zhang S, Wang Z.
europepmc   +1 more source

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

The Journal of Physiology, EarlyView.
Abstract figure legend The present study identified two sub‐populations of gill oxygen sensing neuroepithelial cells (NECs) distinguishable by their stored neurotransmitters – serotonin (5‐hydroxytryptamine, 5‐HT) or acetylcholine (ACh). Using transgenic Tg(elavl3:GCaMP6s) zebrafish, which express an endogenous calcium reporter in neurons, we ...
Maddison Reed, Anthea A. Mavridis, Jan A. Mennigen, Michael G. Jonz   +3 more
wiley   +1 more source

The anti-inflammatory scan: current insights and future perspectives on therapeutic splenic ultrasonography. [PDF]

Ultrasound J
Di Nicolò P, Corradi F.
europepmc   +1 more source

Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we identify key intrinsic properties underlying the distinct biophysical signature of gamma motoneurons (blue): a motoneuron subtype that innervates intrafusal muscle fibres (orange) to adjust spindle afferent (black) sensitivity for detecting muscle length changes during movement.
Simon A. Sharples, Struan J. Nisbet, Matthew J. Broadhead, Dennis Bo Jensen, Francesca L. Sorrell, Claire F. Meehan, Gareth B. Miles   +6 more
wiley   +1 more source