Results 181 to 190 of about 2,347,334 (218)

Chapter 5 Cholinergic innervation and receptors in the cerebellum

1997
We have studied the source and ultrastructural characteristics of ChAT-immunoreactive fibers in the cerebellum of the rat, and the distribution of muscarinic and nicotinic receptors in the cerebellum of the rat, rabbit, cat and monkey, in order to define which of the cerebellar afferents may use ACh as a neurotransmitter, what target structures are ...
Romeo Caffé, Jan Voogd, Enrico Mugnaini, Dick Jaarsma, Allan I. Levey, Constantino Cozzari, Tom J. H. Ruigrok   +6 more
openaire   +3 more sources

Cholinergic receptors in the Aplysia gill

Journal of Neurobiology, 1984
AbstractAcetylcholine has been suggested as a neurotransmitter released in the Aplysia gill by peripheral afferents of central neurons and by peripheral neurons within the gill. The perfused gill, isolated from the abdominal ganglion, was examined. At concentrations greater than 1 μM, acetylcholine elicited a slowly developing tonic contraction of the ...
Samuel Weiss, Samuel Weiss, Jeffrey I. Goldberg, Jon Edstrom, Ken Lukowiak   +4 more
openaire   +3 more sources

The nicotinic cholinergic receptor: A theoretical model

Journal of Neuroscience Research, 1996
Based on published affinity-labeling and mutagenesis experiments describing the effect of changes in specific amino acids in molecular biological studies on the nicotinic acetylcholinergic receptor (nAChR), we have identified 12 amino acids which are important in functioning at the nicotinic cholinergic receptor.
Kenny B. Lipkowitz, M. H. Aprison, E. Galvez-Ruano   +2 more
openaire   +3 more sources

Sex and Gender Differences in the Brain Cholinergic System and in the Response to Therapy of Alzheimer Disease with Cholinesterase Inhibitors.

Current Alzheimer Research, 2018
This review has two aims. First, to examine whether or not sex and gender may influence the brain cholinergic system in animals and in humans. Second, to examine the available evidence of sexually dimorphic response to the therapeutic and toxic effects ...
E. Giacobini, G. Pepeu
semanticscholar   +1 more source

Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.

Science, 1985
Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 ...
D. Mash, D. D. Flynn, L. Potter
semanticscholar   +1 more source

Muscarinic cholinergic receptor heterogeneity

Trends in Neurosciences, 1982
Abstract The relatively recent application of receptor binding techniques to muscarinic receptor pharmacology has provided new data that generally confirm classical ideas about agonist-receptor interactions and competitive antagonism. However, additional information regarding muscarinic receptor heterogeneity has been provided through [ 3 H]ligand ...
William R. Roeske, Frederick J. Ehlert, Henry I. Yamamura   +2 more
openaire   +2 more sources

Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues

Journal of Ocular Pharmacology and Therapeutics, 1985
Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
openaire   +3 more sources

Receptors in neurodegenerative diseases, muscarinic cholinergic receptors

Pharmaceutica Acta Helvetiae, 2000
Publisher Summary Muscarinic acetylcholine receptors are present in the mammalian central nervous system (CNS) and in the periphery. Their stimulation produces inhibitory responses, such as bradycardia and vascular smooth muscle dilatation, and excitatory responses, such as ganglionic depolarization and smooth muscle contraction. Muscarinic receptors
openaire   +4 more sources

Cholinergic receptors in aging and Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1986
Although Alzheimer's disease (AD) is a disorder involving multiple neurotransmitter systems, the basal forebrain cholinergic system (Ch system) is severely and consistently affected in this condition. In both animals and man, the nature of age-associated alterations in the Ch system is unclear. In addition, available studies of cholinergic receptors in
Peter J. Whitehouse, Kin Sing Au
openaire   +3 more sources

Isopilocarpine Binding to Muscarinic Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1986
Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of
James J. O'Donnell, Jon R. Polansky, Michael V. Drake   +2 more
openaire   +3 more sources