Results 191 to 200 of about 2,364,275 (293)

The role of the oral microbiome, host response, and periodontal disease treatment in Alzheimer's disease: A primer

Periodontology 2000, EarlyView.
Abstract Background Alzheimer‘s disease (AD) is the leading cause of cognitive impairment and dementia in elderly patients worldwide. There is increasing evidence that periodontal disease may have an important role in the complex, multifactorial pathogenesis of AD. Aim This narrative review aims to (1) highlight the current understanding of the role of
Jaclyn C. Chalmers, Yvonne L. Hernandez‐Kapila   +1 more
wiley   +1 more source

The Role of α7-Nicotinic Acetylcholine Receptors in the Pathophysiology and Treatment of Parkinson's Disease. [PDF]

Int J Mol Sci
ElNebrisi E, Lozon Y, Oz M.
europepmc   +1 more source

Cholinergic modulation of microglial activation by α7 nicotinic receptors

, 2004
R. Shytle, Takashi Mori, K. Townsend, M. Vendrame, N. Sun, J. Zeng, J. Ehrhart, A. Silver, P. Sanberg, Jun Tan   +9 more
semanticscholar   +1 more source

Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation

Experimental Physiology, EarlyView.
Abstract Total sleep deprivation (TSD) alters local cold tolerance and could thus increase the risk of cold injury. We evaluated the impact of acute caffeine intake, the main countermeasure to TSD‐related deleterious effects, on local cold tolerance before and after TSD.
Baptiste de Lorgeril, Pierre‐Emmanuel Tardo‐Dino, Cyprien Bourrilhon, Michael Quiquempoix, Catherine Drogou, Lise Mateo, Mégane Erblang, Philippe Colin, Pascal Van Beers, Mounir Chennaoui, Danielle Gomez‐Merino, Fabien Sauvet   +11 more
wiley   +1 more source

Novel opportunities for treating complex neuropsychiatric and neurocognitive conditions based on recent developments with xanomeline. [PDF]

Front Psychiatry
Pavlov VA.
europepmc   +1 more source

Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable

Journal of Neuroscience, 2002
M. Matsui, Daisuke Motomura, T. Fujikawa, Jian Jiang, S. Takahashi, T. Manabe, M. Taketo   +6 more
semanticscholar   +1 more source

Integrative cardiovascular dose–response to graded lower‐body negative pressure

Experimental Physiology, EarlyView.
ABSTRACT Lower‐body negative pressure (LBNP) has been posited as a potential spaceflight countermeasure to counteract the physiological deconditioning related to fluid shifts in microgravity. However, open questions remain regarding the magnitude of LBNP that should be applied.
Richard S. Whittle, Nathan Keller, Eric A. Hall, Safiyya Patanam, Bonnie J. Dunbar, Ana Diaz‐Artiles   +5 more
wiley   +1 more source

Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques. [PDF]

J Neurosci
Shin JH, Goldbach HC, Burke DA, Authement ME, Swanson ES, Bocarsly ME, Hernandez S, Kwon HB, Cerveny SE, Mehr JB, Plotnikova AS, Mohanty A, Cummins AC, Pelkey KA, McBain CJ, Khaliq ZM, Eldridge MAG, Averbeck BB, Alvarez VA.   +18 more
europepmc   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

The Journal of Physiology, EarlyView.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source