Results 191 to 200 of about 2,347,334 (218)

Selective blockade of dopamine D3 versus D2 receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis

Journal of Neurochemistry, 2007
Though dopaminergic mechanisms modulate cholinergic transmission and cognitive function, the significance of specific receptor subtypes remains uncertain. Here, we examined the roles of dopamine D3 versus D2 receptors.
M. Millan, B. di Cara, A. Dekeyne, F. Panayi, L. de Groote, D. Sicard, L. Cistarelli, R. Billiras, A. Gobert   +8 more
semanticscholar   +1 more source

Pharmacology of Acetylcholine and Cholinergic Receptors

2020
Acetylcholine is a neurotransmitter that plays a significant role in a variety of physiological functions. Cholinergic neurons synthesize, store, and release acetylcholine and are also responsible for sympathetic and parasympathetic responses of the autonomous nervous system.
Amal Al-Aboudi, Sarah Falah Kokaz, Sara Nidal Abed, Raghu Prasad Mailavaram, Yazan A. Bataineh, Nirupam Das, Pran Kishore Deb, Fatimah Amin Younes, Ruba Anwar Salou, Katharigatta N. Venugopala   +9 more
openaire   +2 more sources

Cholinergic Receptors in the Human vas Deferens

Journal of Receptor Research, 1992
This study represents the first investigation demonstrating the contractile response to exogenous acetylcholine (ACh) in the isolated human vas deferens. Pharmacological characterization of cholinergic receptors was achieved using selective antagonists to define receptor subtypes.
Hugo F. Miranda, O. Castillo, E. Fernandez, C. Paeile, G. Pinardi, Teresa Pelissier, D. Bustamante, P. Salvatierra, Hernan Saavedra   +8 more
openaire   +3 more sources

Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck.

British Journal of Urology, 1975
The adrenergic and cholinergic receptors of the human prostatic capsule, prostatic "adenoma", and bladder neck, were investigated by the in-vitro isometric technique.
M. Caine, Shlomo Raz, M. Zeigler
semanticscholar   +1 more source

Muscarinic cholinergic receptors in goldfish retina

Life Sciences, 1979
Abstract Using 3 H-Quinuclinidyl Benzilate ( 3 H-QNB) as a high affinity ligand for quantitative studies of specific binding to muscarinic cholinergic receptors we have demonstrated the presence of such receptors in homogenates of goldfish retina. Only one set of binding sites could be detected with an apparent dissociation constant of 1.9 × 10 −10
Jose A. Moreno-Yanes, Henry R. Mahler
openaire   +3 more sources

Cholinergic muscarinic receptors in rat cochlea

Brain Research, 1988
Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers.
Wim Kuijpers, J. F. Rodrigues De Miranda, Y.J.B. van Megen, A. B. M. Klaassen   +3 more
openaire   +3 more sources

Lack of localization of 5‐HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5‐HT6 receptor‐mediated acetylcholine release

European Journal of Neuroscience, 2006
The involvement of the cholinergic system in learning and memory together with the cognitive enhancing properties of 5‐HT6 receptor antagonists led us to study the relationship between 5‐HT6 receptors and cholinergic neurotransmission.
B. Marcos, F. Gil-Bea, W. Hirst, M. Garcia-Alloza, M. Ramírez   +4 more
semanticscholar   +1 more source

Affinity Chromatography of Cholinergic Receptor Proteins

Journal of Receptor Research, 1984
Cholinergic binding proteins were purified from torpedo electric organ. The preparation comprises: solubilization by non-ionic detergents followed by unspecific prepurification. For prepurification the double reversed technique proved to be very useful. Finally we applied affinity chromatography.
W. H. Hopff, Peter G. Waser, D. M. Bodmer   +2 more
openaire   +3 more sources

Nicotinic cholinergic receptors in brain synaptosomes

Brain Research, 1979
In order to elucidate pharmacological characteristics of nicotinic receptors in the brain, competitive binding of nicotine analogues or cholinergic agents to brain particles was studied utilizing [3H]nicotine. The binding of [3H]nicotine to brain crude nitochondrial or synaptosomal fraction was progressively inhibited by the addition of increasing ...
Hiroo Imura, Kazuhide Yoshida
openaire   +3 more sources

The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors

1986
Cholinergic synapses in brain undergo dynamic changes during development, maturation and aging. During the life span we can assume that there is a continuous interregulation between presynaptic and postsynaptic activity. In recent years several investigators have shown for example that both muscarine- and nicotine-like receptor binding sites in brain ...
openaire   +2 more sources