Results 21 to 30 of about 2,364,275 (293)

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. [PDF]

PLoS ONE, 2012
Cholinergic depletion in the medial septum (MS) is associated with impaired hippocampal-dependent learning and memory. Here we investigated whether long term potentiation (LTP) and synaptic currents, mediated by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-
Patrick M Kanju, Kodeeswaran Parameshwaran, Catrina Sims-Robinson, Subramaniam Uthayathas, Eleanor M Josephson, Nagalingam Rajakumar, Muralikrishnan Dhanasekaran, Vishnu Suppiramaniam   +7 more
doaj   +1 more source

Cholinergic Stimulation of the Adult Zebrafish Brain Induces Phosphorylation of Glycogen Synthase Kinase-3 β and Extracellular Signal-Regulated Kinase in the Telencephalon

Frontiers in Molecular Neuroscience, 2019
The sequencing of the zebrafish genome, the emergence of powerful gene-editing tools, and the development of in vivo imaging techniques have propelled the economical zebrafish into prominence as a biomedical research model.
Robert A. Mans, Kyle D. Hinton, Cicely H. Payne, Grace E. Powers, Nicole L. Scheuermann, Michael Saint-Jean   +5 more
doaj   +1 more source

Electrophysiology of T lymphocyte cholinergic receptors. [PDF]

Proceedings of the National Academy of Sciences, 1980
The presence of functional muscarinic-cholinergic receptors on at least some T lymphocytes is suggested by the existence of saturable, high-affinity, specific muscarinic binding in T cell-enriched, but not in B cell-enriched, cell suspensions and by observed cholinergic effects on lymphocytes, (e.g., increased lytic capacity of cytotoxic lymphocytes ...
Howard M. Shapiro, Terry B. Strom
openaire   +3 more sources

Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity

Front. Neural Circuits, 2014
Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal cognitive performance. Despite the fact that many have studied how ACh affects neuronal processing in the mPFC and thereby influences attention behavior, there is ...
B. Bloem, R. B. Poorthuis, H. Mansvelder
semanticscholar   +1 more source

Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat

Biochemistry and Biophysics Reports, 2017
Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination.
R. Chinthu, T.R. Anju, C.S. Paulose
doaj   +1 more source

Corelease of acetylcholine and GABA from cholinergic forebrain neurons

eLife, 2015
Neurotransmitter corelease is emerging as a common theme of central neuromodulatory systems. Though corelease of glutamate or GABA with acetylcholine has been reported within the cholinergic system, the full extent is unknown.
Arpiar Saunders, Adam J Granger, Bernardo L Sabatini   +2 more
doaj   +1 more source

Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections

Frontiers in Neural Circuits, 2022
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits.
Chongbo Zhong, Wendy Akmentin, Lorna W. Role, David A. Talmage   +3 more
doaj   +1 more source

Alzheimer's Disease: Targeting the Cholinergic System

Current Neuropharmacology, 2016
Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter
T. H. Ferreira-Vieira, I. M. Guimarães, Flavia R. Silva, F. Ribeiro   +3 more
semanticscholar   +1 more source

Dopamine and Serotonin-Induced Modulation of GABAergic and Glutamatergic Transmission in the Striatum and Basal Forebrain

Frontiers in Neuroanatomy, 2017
Catecholamine receptor-mediated modulation of glutamatergic or GABAergic transmission in the striatum as well as basal forebrain (BF) has been intensively studied during these two decades.
Toshihiko Momiyama, Takuma Nishijo
doaj   +1 more source

Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice

Nature Communications, 2023
Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like and depression-like behaviour.
Ya-Wei Ji, Zi-Lin Shen, Xue Zhang, Kairan Zhang, Tao Jia, Xiangying Xu, Huizhen Geng, Yu Han, Cui Yin, Jian-Jun Yang, Jun-Li Cao, Chunyi Zhou, Cheng Xiao   +12 more
doaj   +1 more source