Results 31 to 40 of about 2,347,334 (218)
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Alzheimer's Disease: Targeting the Cholinergic System
Current Neuropharmacology, 2016 Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter
T. H. Ferreira-Vieira +3 more
semanticscholar +1 more source
Frontiers in Neural Circuits, 2022 Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits.
Chongbo Zhong +3 more
doaj +1 more source
Using ResNet to Utilize 4-class T2-FLAIR Slice Classification Based on the Cholinergic Pathways Hyperintensities Scale for Pathological Aging [PDF]
arXiv, 2023 The Cholinergic Pathways Hyperintensities Scale (CHIPS) is a visual rating scale used to assess the extent of cholinergic white matter hyperintensities in T2-FLAIR images, serving as an indicator of dementia severity. However, the manual selection of four specific slices for rating throughout the entire brain is a time-consuming process.
arxiv
Frontiers in Neuroanatomy, 2017 Catecholamine receptor-mediated modulation of glutamatergic or GABAergic transmission in the striatum as well as basal forebrain (BF) has been intensively studied during these two decades.
Toshihiko Momiyama, Takuma Nishijo
doaj +1 more source
Nature Communications, 2023 Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like and depression-like behaviour.
Ya-Wei Ji +12 more
doaj +1 more source
Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
Frontiers in Neural Circuits, 2017 This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation.
Holger Dannenberg +2 more
doaj +1 more source
Central Cholinergic Nervous System and Cholinergic Agents
Acta Medica, 1998 Central cholinergic nervous system play important role in many physiological and behavioral functions in humans. The activity of the cholinergic nervous system depends upon the production and fate of acetylcholine and all compounds influenced its ...
Jiří Patočka
doaj +1 more source
Cholinergic Signaling, Neural Excitability, and Epilepsy
Molecules, 2021 Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission ...
Yu Wang, Bei Tan, Yi Wang, Zhong Chen
doaj +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source