Results 71 to 80 of about 2,364,275 (293)

ТИТРЫ АНТИТЕЛ К β1-АДРЕНОРЕЦЕПТОРАМ И М2-ХОЛИНОРЕЦЕПТОРАМ У БОЛЬНЫХ С ЖЕЛУДОЧКОВЫМИ НАРУШЕНИЯМИ РИТМА СЕРДЦА БЕЗ ПРИЗНАКОВ ОРГАНИЧЕСКОГО ЗАБОЛЕВАНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ И ИХ ВОЗМОЖНОЕ КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ

Рациональная фармакотерапия в кардиологии, 2015
Aim. To identify the most promising epitopes that simulate various sites β1-adrenergic and M2-cholinergic receptors, and to evaluate their possible contribution to the development and maintenance of cardiac arrhythmias, particularly idiopathic ...
M. M. Rogova, N. A. Mironova, E. S. Rodionova, T. A. Malkina, K. A. Zykov, Zh. D. Bespalova, R. Sh. Bibilashvili, E. E. Efremov, S. P. Golitsyn   +8 more
doaj   +1 more source

The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim, Cheon Hee Park, Seong Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Chemical Characterization, Antioxidant, and Anticholinesterase Activities of Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz and In Silico Studies with the Acetylcholinesterase Enzyme

Chemistry &Biodiversity, EarlyView.
ABSTRACT Libidibia ferrea is used in many parts of Brazil for a variety of conditions, such as inflammation, respiratory disorders, muscle pain, and gastrointestinal problems. This study evaluated the chemistry and antioxidant and acetylcholinesterase (AChE) inhibitory activities of L. ferrea extracts. Hydroethanolic extracts of leaves (ELLF) and bark (
Lucas Soares Frota, Sara Ingrid Caetano Gomes Barbosa, Camila Costa Feitosa, Francisco Flávio da Silva Lopes, Daniel Pereira de Oliveira, Leonardo Soares Freitas, Adriano Lincoln Albuquerque Mattos, Wildson Max Barbosa da Silva, Hamilton Mitsugu Ishiki, Selene Maia de Morais   +9 more
wiley   +1 more source

The Molecular Properties of Honey Bee Acetylcholinesterase Reveal Opportunities to Avoid Off‐Target Effects in Insecticide Discovery

Chemistry – A European Journal, EarlyView.
The structure, dynamics, and kinetics of the essential enzyme acetylcholinesterase (AChE) of honey bee have been studied and compared to AChEs in mosquitoes and mammalians. Profiling of the active sites with selected substrates and AChE inhibitors revealed dramatic differences between the species.
Cecilia Lindgren, Rajeshwari Rajeshwari, Cecilia Springer Engdahl, Rashmi Kumari, Fredrik Ekström, Anna Linusson   +5 more
wiley   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Perampanel as a second‐line therapy to midazolam reduces soman‐induced status epilepticus and neurodegeneration in rats

Epilepsia Open, EarlyView.
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier, Caroline R. Schultz, Jerome Niquet, Donna A. Nguyen, Michael F. Stone, Abiel K. Biney, Marcio de Araujo Furtado, Claude G. Wasterlain, Lucille A. Lumley   +8 more
wiley   +1 more source

Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons

Frontiers in Cellular Neuroscience, 2016
The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao, Kang eZhang, Xiaoyan eLiu, Haitao eYan, Xiaoyun eMa, Shuzhuo eZhang, Jianquan eZheng, Liyun eWang, Xiaoli eWei   +8 more
doaj   +1 more source

The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.

Journal of Neuropathology and Experimental Neurology, 2005
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic cortical projection neurons in end stage Alzheimer disease (
S. Counts, E. Mufson
semanticscholar   +1 more source