Results 101 to 110 of about 3,062,816 (304)

Complement Activation and Progression of Chronic Kidney Disease [PDF]

, 2009
Proteinuria is a strong predictor of progression in chronic kidney disease. Complement proteins are a major constituent of the urine of proteinuric patients.
Sheerin, Neil, Tang, Ziyong
core   +1 more source

Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

Cancer Research, 2018
The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression.
Jeff W. Kwak, J. Laskowski, Howard Y. Li, M. McSharry, Trisha R Sippel, Bonnie L. Bullock, Amber M. Johnson, J. Poczobutt, A. Neuwelt, S. Malkoski, M. Weiser-Evans, John D Lambris, E. Clambey, J. Thurman, R. Nemenoff   +14 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation [PDF]

Journal of Clinical Investigation, 2003
In a strategy to specifically target complement inhibitors to sites of complement activation and disease, recombinant fusion proteins consisting of a complement inhibitor linked to a C3 binding region of complement receptor (CR) 2 were prepared and characterized.
Stephen Tomlinson, Chun He, V. Michael Holers, Christian Knaak, Hongbin Song, Joel M. Guthridge   +5 more
openaire   +3 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. [PDF]

PLoS ONE, 2015
Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen.
Joakim J E Bergström, Birgitta Heyman
doaj   +1 more source

Unstable Angina is a syndrome correlated to mixed Th17 and Th1 immune disorder [PDF]

arXiv, 2013
Unstable angina is common clinical manifestation of atherosclerosis. However, the detailed pathogenesis of unstable angina is still not known. Here, I propose that unstable angina is a mixed TH17 and TH1 immune disorder. By using microarray analysis, I find out that TH1 and TH17 related cytokine, cytokine receptor, chemokines, complement, immune ...
arxiv  

Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]

, 2005
The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ, Giles, IP, Ioannou, Y, Rahman, A   +3 more
core   +1 more source

Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus.

Blood, 2010
Pentraxin 3 (PTX3) is a soluble pattern recognition molecule playing a nonredundant role in resistance against Aspergillus fumigatus. The present study was designed to investigate the molecular pathways involved in the opsonic activity of PTX3.
F. Moalli, A. Doni, Livija Deban, T. Zelante, S. Zagarella, B. Bottazzi, L. Romani, A. Mantovani, C. Garlanda   +8 more
semanticscholar   +1 more source