Results 81 to 90 of about 1,111,234 (301)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Clinical and Developmental Immunology, 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway.
Peter D. Gorevic
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi [PDF]

, 2010
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.
Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard   +34 more
core   +2 more sources

Blockage of CR1 prevents activation of rodent microglia

Neurobiology of Disease, 2013
The importance of the complement system in Alzheimer's disease (AD) pathogenesis has been emphasized through recent genome wide association studies. However, the cellular and molecular role of these complement proteins is not fully understood.
Helen Crehan, John Hardy, Jennifer Pocock   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement [PDF]

, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Matthew L Rotondi, Trevor P Creamer, Henry A. Choy, Brissette Catherine A., Kraiczy Peter, DeMoll, Edward, Edward Demoll, Peter Kraiczy, Stevenson, Brian, Suchard, Marc A, Creamer, Trevor P., Cooley Anne E., Matthew L. Rotondi, Kraiczy, Peter, Suchard, Marc A., Marc A. Suchard, Haake David A., Marija Pinne, Brissette, Catherine A, Catherine A. Brissette, Cooley, Anne E., Marc A Suchard, DeMoll Edward, Creamer, Trevor P, Pinne Marija, Verma, Ashutosh, Miller M. Clarke, Choy Henry A., Miller, M. Clarke, M Clarke Miller, Choy, Henry A, Pinne, Marija, Catherine A Brissette, Trevor P. Creamer, Verma Ashutosh, Haake, David A, Anne E. Cooley, Brissette, Catherine A., Rotondi, Matthew L., Suchard Marc A., Stevenson Brian, Creamer Trevor P., Brian Stevenson, Ashutosh Verma, M. Clarke Miller, Miller, M Clarke, Rotondi, Matthew L, Haake, David A., Rotondi Matthew L., Henry A Choy, David A Haake, Cooley, Anne E, Choy, Henry A., Anne E Cooley, David A. Haake   +54 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source