Results 71 to 80 of about 344,062 (307)

Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world.
María Belén Caputo, Josefina Elias, Gonzalo Cesar, María Gabriela Alvarez, Susana Adriana Laucella, Susana Adriana Laucella, María Cecilia Albareda   +6 more
doaj   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura, Giusti, Pietro, Skaper, Stephen D., Zusso, Morena   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Clinical and Developmental Immunology, 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway.
Peter D. Gorevic
doaj   +1 more source

Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection

Retrovirology, 2011
Background Non-neutralising antibodies to the envelope glycoprotein are elicited during acute HIV-1 infection and are abundant throughout the course of disease progression.
Williams Ian, Pellegrino Pierre, O'Farrell Stephen, Aasa-Chapman Marlén MI, Willey Suzanne, Weiss Robin A, Neil Stuart JD   +6 more
doaj   +1 more source

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway [PDF]

, 2015
Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brown, Gordon D, Chen, Wen-Yu, Chu, Ching-Liang, Chuu, Chih-Pin, Huang, Juin-Hua, Lin, Ching-Yu, Wu, Sheng-Yang, Wu-Hsieh, Betty A   +7 more
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intracellular C3 regulates the immune response to infection via NF-κB signaling

Cellular and Molecular Life Sciences
Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment.
Katarzyna Kuska, Serena Bettoni, Frida Mohlin, Maja Chrobak, Vaishnavi Dandavate, Saleh Moradi, Ben King, Kristian Riesbeck, Anna M. Blom   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]

, 2013
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
A Demissie, A Raja, A Regnault, A Williams, AF Cunningham, AN Antoniou, AR Berengian, AS Mustafa, B Heyman, BC Schalke, CK Kennaway, Craig van Dolleweerd, CT Cady, D Chargelegue, D Matheoud, DH Schuurhuis, E Celis, E Celis, EJ Wiersma, Elena Stylianou, EM Leyten, F Manca, F Pinheiro da Silva, F Villinger, F Winau, G Falero-Diaz, G Terres, GG Klaus, Gil Reynolds Diogo, H Boesen, Ilaria Pepponi, J Laissue, JM den Haan, Julian K.-C. Ma, K Osato, KB Reid, M Jacobsen, Matthew J. Paul, MF Bachmann, N Caccamo, N Polyanskaya, P Andersen, Pascal M. W. Drake, PD Simitsek, Pere-Joan Cardona, PM Guyre, PM Hogarth, PS Jackett, Q Li, R Jemmerson, R Pal, R Reljic, R Reljic, Rajko Reljic, RG Taylor, RJ Eisenberg, RJ Wilkinson, S Marusic-Galesic, SA Moreno-Mendieta, SA Plotkin, U Abdel-Motal, V Roupie, W Phoolcharoen, WE Houston, WR Heath, Y Yuan, Y Yuan, YM Wen, Z Chang   +68 more
core   +2 more sources