Results 11 to 20 of about 3,314,611 (329)
iScience, 2023 Summary: Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD.
Ai Na Ng +4 more
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Helix 8 in chemotactic receptors of the complement system.
PLoS Computational Biology, 2022 Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski +3 more
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Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
Molecular Therapy: Methods & Clinical Development, 2023 High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami +11 more
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eLife, 2020 The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
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Receptor-Mediated NETosis on Neutrophils
Frontiers in Immunology, 2021 Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection.
Tao Chen +19 more
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Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
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Complement System: An Immunotherapy Target in Colorectal Cancer
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat +7 more
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C3‐dependent effector functions of complement
Immunological Reviews, 2022 C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments
A. Zarantonello +3 more
semanticscholar +1 more source
Acta Neuropathologica Communications, 2023 Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations.
Amer Toutonji +5 more
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Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice
Frontiers in Immunology, 2021 Complement impacts innate and adaptive immunity. Using a model in which the human KEL glycoprotein is expressed on murine red blood cells (RBCs), we have shown that polyclonal immunoprophylaxis (KELIg) prevents alloimmunization to transfused RBCs when a ...
Vicente Escamilla-Rivera +16 more
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