Results 21 to 30 of about 193,049 (264)

CR2 Complement Receptor

Journal of Investigative Dermatology, 1990
CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes, follicular dendritic cells in lymphoid organs, and epithelial cells, interacts preferentially with C3dg, the terminal activation/processing fragment of the third ...
Cooper, Neil R, Bradt, Bonnie M, Rhim, Johng S, Nemerow, Glen R   +3 more
openaire   +2 more sources

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source

Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India

Safety and Health at Work, 2017
Background: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. Methods: Seventy-four
Nandan K. Mondal, Shabana Siddique, Madhuchanda Banerjee, Sanghita Roychoudhury, Sayali Mukherjee, Mark S. Slaughter, Twisha Lahiri, Manas R. Ray   +7 more
doaj   +1 more source

Neuropilin-1 Acts as a Receptor for Complement Split Products

Frontiers in Immunology, 2019
Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection.
Claire Battin, Annika De Sousa Linhares, Wolfgang Paster, Wolfgang Paster, David E. Isenman, Markus Wahrmann, Judith Leitner, Gerhard J. Zlabinger, Peter Steinberger, Johannes Hofer   +9 more
doaj   +1 more source

Anaphylatoxins spark the flame in early autoimmunity

Frontiers in Immunology, 2022
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher, Jörg Köhl, Jörg Köhl, Christian M. Karsten   +3 more
doaj   +1 more source

Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein. [PDF]

PLoS Pathogens, 2008
Many pathogens are equipped with factors providing resistance against the bactericidal action of complement. Yersinia enterocolitica, a Gram-negative enteric pathogen with invasive properties, efficiently resists the deleterious action of human ...
Vesa Kirjavainen, Hanna Jarva, Marta Biedzka-Sarek, Anna M Blom, Mikael Skurnik, Seppo Meri   +5 more
doaj   +1 more source

Complement receptor is an inhibitor of the complement cascade. [PDF]

The Journal of experimental medicine, 1981
A glycoprotein from the membrane of human erythrocytes has been identified as a receptor for C3b (CR1). It promotes the dissociation of the alternative pathway C3 convertase C3b,Bb and the cleavage of C3b by C3b/C4b inactivator. We find that CR1 also inactivates the C3 and C5 convertases of the classical pathway.
K, Iida, V, Nussenzweig
openaire   +2 more sources

Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity

Frontiers in Immunology, 2020
Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. Innate and adaptive immune responses
Wilfried Posch, Marta Bermejo-Jambrina, Marta Bermejo-Jambrina, Cornelia Lass-Flörl, Doris Wilflingseder   +4 more
doaj   +1 more source

Engineered Trivalent Human IgG1-Fc Proteins for Potent Complement Inhibition

Cells
High-dose intravenous immunoglobulin (IVIG) is used to treat autoimmune and inflammatory diseases, and several studies demonstrate that the therapeutic effects of IVIG can be recapitulated with the fragment crystallizable (Fc) portion.
Ian K. Campbell, Daniel Ortiz, Carlos Bosques, Matthew P. Hardy, Andrea Tester, Vesna Tomasetig, Daniel Couto, Thomas Gentinetta, Sabine Pestel, Padmapriya Ponnuswamy, Fabian Käsermann, Rolf Spirig   +11 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source