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Structural biology of complement receptors [PDF]
Frontiers in Immunology, 2023 The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer.
Jorge Santos-López +4 more
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Engineered Trivalent Human IgG1-Fc Proteins for Potent Complement Inhibition [PDF]
CellsHigh-dose intravenous immunoglobulin (IVIG) is used to treat autoimmune and inflammatory diseases, and several studies demonstrate that the therapeutic effects of IVIG can be recapitulated with the fragment crystallizable (Fc) portion.
Ian K. Campbell +11 more
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Neuroimmune interactions: from molecular mechanisms to therapeutic targets [PDF]
Molecular BiomedicineNeuroimmune interactions reveal that the central nervous system (CNS) is dynamically integrated with peripheral immunity. This bidirectional communication is mediated by microglia, astrocytes, peripheral immune cells, and the neurovascular unit through ...
Yi-hang Hao +3 more
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Complement tumor-crosstalk: the role of C5a receptors in urothelial carcinomas [PDF]
Frontiers in ImmunologyUrothelial carcinoma, the second most common urological malignancy, can arise in both the lower and upper urinary tract, with approximately 90–95% arising in the bladder, while urothelial carcinomas of the upper urinary tract account for only 5–10 ...
Lea Sophie Lütje +4 more
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A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome” [PDF]
Frontiers in NephrologyThe complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through three main activation pathways: classical, lectin, and
Emre Leventoğlu, Sevcan A. Bakkaloğlu
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Structure and specificity of complement receptors
Immunology Letters, 1987 Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these--CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein--interact with C3 or C4 and their degradation products.
Sim, R. B. +3 more
openaire +4 more sources
Contribution of receptors to 'Neisseria meningitidis' interactions with human macrophages [PDF]
, 2004 N. meningitidis is a gram-negative human pathogen that invades human cells, evades immune responses and goes on to cause meningococcal disease, sepsis and death.
Abdillahi, Fatumo Abdi
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Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis
Frontiers in Cell and Developmental Biology, 2021 The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Sofie Vandendriessche +3 more
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The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
core +1 more source
An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer
Antibodies, 2021 The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir +11 more
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