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Complement factors and their receptors
Immunopharmacology, 1997In summary, recent advances in molecular cloning of anaphylatoxins and the anaphylatoxin receptors add new dimensions to our investigations and understanding of the molecular mechanisms involved in anaphylatoxin action. Combining knowledge accumulated from peptide modeling of the ligands with mutagenesis studies of these ligands and their receptors ...
Julia A. Ember, Tony E. Hugli
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Characterization of complement receptors
Molecular Immunology, 1982During recent years the research on the biochemistry and biology of complement receptors has made considerable progress, since not only the ligands but also the receptors have been better defined. In this contribution we describe the present status including data from the literature and our own laboratory.
Manfred P. Dierich +5 more
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Complement Receptors and Cell Associated Complement Components
Immunological Communications, 1977Membrane receptors for activated complement components are widely distributed amongst tissue cells of most mammalian species. Common amongst these are receptors for C3b which mediate many of the biological functions of C3. In addition, the genetic control of certain complement components is linked to the genes which code for the major ...
P. J. Lachmann, Ian McConnell
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Complement receptors and phagocytosis
Current Opinion in Immunology, 1991Current understanding of the molecular mechanisms involved in regulating the phagocytic function of monocytes, macrophages and polymorphonuclear leukocytes is summarized, giving emphasis to the role of the phagocyte integrins of the CD11/CD18 family. New data relating to the hypotheses that optimal function of these receptors is a property of activated
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Structure and specificity of complement receptors
Immunology Letters, 1987Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these--CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein--interact with C3 or C4 and their degradation products.
Sim, R. B. +3 more
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Erythrocyte Complement Receptors
Critical Reviews™ in Immunology, 1995Primate erythrocytes express complement receptors (E-CR), which can extrinsically bind C3b and Cb4. This interaction allows primate erythrocytes to bind complement opsonized particles and immune complexes, a phenomenon historically referred to as immune adherence. The binding of C3b and C4b by E-CR also leads to inhibition of complement activation. The
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Complement Receptors in HIV Infection
Current Molecular Medicine, 2002Similar to other pathogens, HIV can directly activate the complement pathway even in the absence of antibodies. During and after seroconversion, HIV-specific antibodies enhance the activation of complement and increase deposition of complement fragments on virions dramatically.
Heribert Stoiber +4 more
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Assays for Membrane Complement Receptors
Current Protocols in Immunology, 1994AbstractLeukocytes express several types of receptors for activated products of the complement (C) system. This unit describes assays for a subset of these receptors: those specific for fixed fragments of C3 (CR1, CR2, CR3, and CR4). Although the assays have been designed for tests of human C receptors, they can often be carried out with rodent (e.g ...
Lynda D. O'Rear, Gordon D. Ross
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Complement Receptors in Neutrophils
Critical Reviews™ in Immunology, 1995Human neutrophils contain numerous intracellular granules and vesicles that are exocytosed in a hierarchic manner on stimulation of the neutrophil with inflammatory mediators. Secretory vesicles are mobilized completely to the plasma membrane when neutrophils are stimulated with inflammatory mediators in nanomolar concentrations. There is evidence that
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Complement Receptors in Shock and Transplantation
Archives of Surgery, 1993Over the last decade, elegant studies of the basic biologic characteristics of inflammation and tissue injury have implicated leukocyte-mediated vascular and tissue injury in the pathogenesis of a wide variety of immune and inflammatory clinical disorders, including allograft rejection, adult respiratory distress syndrome, and shock. Recognition of the
Edwin A. Deitch, Mary C. Mancini
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