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Structure and specificity of complement receptors
Immunology Letters, 1987 Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these--CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein--interact with C3 or C4 and their degradation products.
Sim, R. B. +3 more
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Current Opinion in Immunology, 1992
Recently, a number of exciting developments have increased our understanding of complement receptors. These advances include determination of the spatial organization of the short consensus repeat unit, analysis of active sites within short consensus repeats, downregulation in vivo of the complement system by a recombinant receptor, elucidation of the ...
M, Krych, J P, Atkinson, V M, Holers
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Recently, a number of exciting developments have increased our understanding of complement receptors. These advances include determination of the spatial organization of the short consensus repeat unit, analysis of active sites within short consensus repeats, downregulation in vivo of the complement system by a recombinant receptor, elucidation of the ...
M, Krych, J P, Atkinson, V M, Holers
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Characterization of complement receptors
Molecular Immunology, 1982During recent years the research on the biochemistry and biology of complement receptors has made considerable progress, since not only the ligands but also the receptors have been better defined. In this contribution we describe the present status including data from the literature and our own laboratory.
M P, Dierich +5 more
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Complement factors and their receptors
Immunopharmacology, 1997In summary, recent advances in molecular cloning of anaphylatoxins and the anaphylatoxin receptors add new dimensions to our investigations and understanding of the molecular mechanisms involved in anaphylatoxin action. Combining knowledge accumulated from peptide modeling of the ligands with mutagenesis studies of these ligands and their receptors ...
J A, Ember, T E, Hugli
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Complement receptors and phagocytosis
Current Opinion in Immunology, 1991Current understanding of the molecular mechanisms involved in regulating the phagocytic function of monocytes, macrophages and polymorphonuclear leukocytes is summarized, giving emphasis to the role of the phagocyte integrins of the CD11/CD18 family. New data relating to the hypotheses that optimal function of these receptors is a property of activated
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Complement Receptors in Neutrophils
Critical Reviews™ in Immunology, 1995Human neutrophils contain numerous intracellular granules and vesicles that are exocytosed in a hierarchic manner on stimulation of the neutrophil with inflammatory mediators. Secretory vesicles are mobilized completely to the plasma membrane when neutrophils are stimulated with inflammatory mediators in nanomolar concentrations. There is evidence that
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Erythrocyte Complement Receptors
Critical Reviews™ in Immunology, 1995Primate erythrocytes express complement receptors (E-CR), which can extrinsically bind C3b and Cb4. This interaction allows primate erythrocytes to bind complement opsonized particles and immune complexes, a phenomenon historically referred to as immune adherence. The binding of C3b and C4b by E-CR also leads to inhibition of complement activation. The
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Complement Receptors and Cell Associated Complement Components
Immunological Communications, 1977Membrane receptors for activated complement components are widely distributed amongst tissue cells of most mammalian species. Common amongst these are receptors for C3b which mediate many of the biological functions of C3. In addition, the genetic control of certain complement components is linked to the genes which code for the major ...
I, McConnell, P J, Lachmann
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The Chemistry and Biology of Complement Receptors
Springer Seminars in Immunopathology, 1984Activation of the complement system gives rise to a number of molecular species which can interact with host-derived cells and regulate their function. This interaction is mediated through distinct cell surface complement receptors, and receptor engagement produces biologic responses which can either modulate host defense reactions or enhance ...
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