Results 21 to 30 of about 3,314,611 (329)

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice

mSphere, 2017
Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs ...
Sarah J. Kane, Eric Swanson, Elizabeth O. Gordon, Savannah Rocha, Heather R. Bender, Luke R. Donius, Adriano Aguzzi, Jonathan P. Hannan, Mark D. Zabel   +8 more
doaj   +1 more source

Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling

Biomedicines, 2023
Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher, Heike M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment

Cells, 2020
The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles.
Alvaro Torres-Gomez, Jose Luis Sanchez-Trincado, Víctor Toribio, Raul Torres-Ruiz, Sandra Rodríguez-Perales, María Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente   +8 more
doaj   +1 more source

CR3 is the dominant phagocytotic complement receptor on human dendritic cells. [PDF]

, 2013
Dendritic cells (DCs) play a decisive role in immunity; they interact with various pathogens via several pattern recognition and different opsonophagocytotic receptors, including Fc- and complement-receptors. beta2-integrins, including complement
Abram, Anna Erdei, Bajtay, Bajtay, Behrens, Berton, Birdsall, Bretscher, Bunting, Capron, Carroll, Carroll, Domonkos Pap, Dupuy, Ehirchiou, Erdei, Erdei, Fabry, Gelderman, Gelderman, Georgakopoulos, Gergely, Graham, Gresham, Kacani, Katalin Kristóf, Katalin Paréj, Kemper, Kerekes, Li, Liu, MacPherson, Maison, Morelli, Nauta, Nauta, Noémi Sándor, Oliva, Papp, Pickl, Prechtel, Rosen, Ross, Sandor, Schmidt, Skoberne, Sohn, Turner, Török, van Spriel, van Spriel, Varga, Veldhoen, Verbovetski, Vignali, Wagner, Zsuzsa Bajtay   +56 more
core   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

Neutrophil chemoattractant receptors in health and disease: double-edged swords

Cellular & Molecular Immunology, 2020
Neutrophils are frontline cells of the innate immune system. These effector leukocytes are equipped with intriguing antimicrobial machinery and consequently display high cytotoxic potential. Accurate neutrophil recruitment is essential to combat microbes
Mieke Metzemaekers, M. Gouwy, P. Proost
semanticscholar   +1 more source

CR2 Complement Receptor

Journal of Investigative Dermatology, 1990
CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes, follicular dendritic cells in lymphoid organs, and epithelial cells, interacts preferentially with C3dg, the terminal activation/processing fragment of the third ...
Cooper, Neil R, Bradt, Bonnie M, Rhim, Johng S, Nemerow, Glen R   +3 more
openaire   +2 more sources

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source