Results 21 to 30 of about 3,062,816 (304)

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2020
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xiang X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A., Woodruff, Trent M.   +8 more
core   +2 more sources

Complement receptor is an inhibitor of the complement cascade. [PDF]

The Journal of experimental medicine, 1981
A glycoprotein from the membrane of human erythrocytes has been identified as a receptor for C3b (CR1). It promotes the dissociation of the alternative pathway C3 convertase C3b,Bb and the cleavage of C3b by C3b/C4b inactivator. We find that CR1 also inactivates the C3 and C5 convertases of the classical pathway.
Iida K, Nussenzweig
openaire   +2 more sources

Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice

Frontiers in Immunology, 2021
Complement impacts innate and adaptive immunity. Using a model in which the human KEL glycoprotein is expressed on murine red blood cells (RBCs), we have shown that polyclonal immunoprophylaxis (KELIg) prevents alloimmunization to transfused RBCs when a ...
Vicente Escamilla-Rivera, Manjula Santhanakrishnan, Jingchun Liu, David R. Gibb, James E. Forsmo, James E. Forsmo, Ellen F. Foxman, Ellen F. Foxman, Stephanie C. Eisenbarth, Stephanie C. Eisenbarth, C. John Luckey, James C. Zimring, Krystalyn E. Hudson, Sean R. Stowell, Sean R. Stowell, Jeanne E. Hendrickson, Jeanne E. Hendrickson   +16 more
doaj   +1 more source

Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes

Acta Neuropathologica Communications, 2023
Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations.
Amer Toutonji, Carsten Krieg, Davis M. Borucki, Mamatha Mandava, Silvia Guglietta, Stephen Tomlinson   +5 more
doaj   +1 more source

Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]

J Cell Biochem (2021) 1-8, 2020
The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv   +1 more source

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice

mSphere, 2017
Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs ...
Sarah J. Kane, Eric Swanson, Elizabeth O. Gordon, Savannah Rocha, Heather R. Bender, Luke R. Donius, Adriano Aguzzi, Jonathan P. Hannan, Mark D. Zabel   +8 more
doaj   +1 more source

Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling

Biomedicines, 2023
Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher, Heike M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment

Cells, 2020
The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles.
Alvaro Torres-Gomez, Jose Luis Sanchez-Trincado, Víctor Toribio, Raul Torres-Ruiz, Sandra Rodríguez-Perales, María Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente   +8 more
doaj   +1 more source

Ontogeny of the antibody-forming cell line in mice. IV. Appearance of cells bearing Fc receptors, complement receptors, and surface immunoglobulin.

Journal of Immunology, 1977
The ontogeny of Ig, FcR, and CR-bearing cells in liver and spleen has been followed by using rosetting procedures. These studies demonstrated a sequential appearance of surface receptors during development.
Y. Rosenberg, C. Parish
semanticscholar   +1 more source