Modulation of granulocyte LAM-1 and MAC-1 during dialysis—A prospective, randomized controlled trial [PDF]
, 1992 Modulation of granulocyte LAM-1 and MAC-1 during dialysis—A prospective, randomized controlled trial. Hemodialysis with first-use cellulosic dialysis membranes results in activation of the alternative pathway of complement and profound neutropenia ...
Hakim, Raymond +3 more
core +1 more source
A promising approach for the real-time quantification of cytosolic protein-protein interactions in living cells [PDF]
, 2020 In recent years, cell-based assays have been frequently used in molecular interaction analysis. Cell-based assays complement traditional biochemical and biophysical methods, as they allow for molecular interaction analysis, mode of action studies and even drug screening processes to be performed under physiologically relevant conditions.
arxiv +1 more source
Receptors for Complement on Langerhans Cells
Journal of Investigative Dermatology, 1980 A population of guinea pig epidermal cells, identified as Langerhans cells, formed rosettes with sheep erythrocytes coated with IgM immunoglobulin and C3b (EAC1-3b) but not with intermediates carrying only C1, C14b, or C14b2a. These findings were unusual since most other cells expressing C3b receptors also express C4b receptors.
Karen Burke, Irma Gigli
openaire +3 more sources
Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
Molecular Therapy: Methods & Clinical Development, 2023 High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami +11 more
doaj
Complement-targeted therapies in kidney transplantation—insights from preclinical studies
Frontiers in Immunology, 2022 Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure. In kidney transplantation, the complement system is implicated in the pathogenesis of antibody- and cell-mediated rejection, ischemia-reperfusion ...
Imran J. Anwar +5 more
doaj +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
Mast cells and complement system: Ancient interactions between components of innate immunity
Allergy. European Journal of Allergy and Clinical Immunology, 2020 The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the
Daniel Elieh-Ali-Komi +3 more
semanticscholar +1 more source
Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity
Frontiers in Immunology, 2020 Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. Innate and adaptive immune responses
Wilfried Posch +4 more
doaj +1 more source
The Complement System: A Potential Therapeutic Target in Liver Cancer
Life, 2022 Liver cancer is the sixth most common cancer and the fourth most fatal cancer in the world. Immunotherapy has already achieved modest results in the treatment of liver cancer.
Meng Yuan +4 more
doaj +1 more source
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]
, 2012 BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman +8 more
core +2 more sources