Results 71 to 80 of about 3,062,816 (304)

The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review

International Journal of Inflammation, 2010
Neurons and glia respond to acute injury by participating in the CNS innate immune response. This involves the recognition and clearance of “not self ” pathogens and “altered self ” apoptotic cells.
M. R. Griffiths, P. Gasque, J. W. Neal
doaj   +1 more source

Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world.
María Belén Caputo, Josefina Elias, Gonzalo Cesar, María Gabriela Alvarez, Susana Adriana Laucella, Susana Adriana Laucella, María Cecilia Albareda   +6 more
doaj   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source

Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System

Frontiers in Immunology, 2019
The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease.
Sarah M Carpanini, Megan Torvell, B. Morgan   +2 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Assay of cardiopulmonary bypass system for porcine alveolar macrophages removing GFP-E. coli from erythrocyte surfaces [PDF]

PeerJ
While it is established that complement receptor molecules on the surface of erythrocytes are crucial for the clearance of immune complexes in the body, the molecular mechanisms underlying the interaction between macrophages and erythrocytes in pigs ...
Yongqiang Liu, Nan Wang, Qing Ru, Kuohai Fan, Na Sun, Panpan Sun, Hongquan Li, Wei Yin   +7 more
doaj   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor [PDF]

The Journal of Immunology, 2005
AbstractThe complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and membrane regulators. We describe complement C2 receptor inhibitor trispanning (CRIT), a novel human complement regulatory receptor, expressed on hemopoietic cells and a wide range of ...
Jürg-A. Schifferli, Gerhard R. F. Krueger, Kwok Min Hui, Sylvie Miot, Marcel I. Ramirez, Brigitte Schneider, Sigrun Lange, Jameel M. Inal   +7 more
openaire   +3 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Future perspectives in target-specific immunotherapies of myasthenia gravis

Therapeutic Advances in Neurological Disorders, 2015
Myasthenia gravis (MG) is an autoimmune disease caused by complement-fixing antibodies against acetylcholine receptors (AChR); antigen-specific CD4+ T cells, regulatory T cells (Tregs) and T helper (Th) 17+ cells are essential in antibody production ...
Marinos C. Dalakas
doaj   +1 more source