Results 61 to 70 of about 22,074 (250)

High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones

Journal of Immunology Research, 2020
Despite the shared pattern of surface antigens, neoplastic cells in chronic lymphocytic leukemia (CLL) are highly heterogeneous in CD5 expression, a marker linked to a proliferative pool of neoplastic cells.
Gayane Manukyan, Tomas Papajik, Zuzana Mikulkova, Renata Urbanova, Veronika Smotkova Kraiczova, Jakub Savara, Milos Kudelka, Peter Turcsanyi, Eva Kriegova   +8 more
doaj   +1 more source

The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis [PDF]

Journal of Clinical Investigation, 1999
B- and T-cell recirculation is crucial for the function of the immune system, with the control of cell migration being mainly mediated by several chemokines and their receptors. In this study, we investigated the expression and function of CXCR3 on normal and malignant B cells from 65 patients with chronic lymphoproliferative disorders (CLDs). Although
TRENTIN, LIVIO, AGOSTINI, CARLO, FACCO, MONICA, PIAZZA, FRANCESCO, PERIN A., SIVIERO M., GURRIERI C., GALVAN S., ADAMI, FAUSTO, ZAMBELLO R., SEMENZATO, GIANPIETRO CARLO   +10 more
openaire   +3 more sources

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of idiopathic nonspecific interstitial pneumonia

, 2007
SummaryLittle is known about the role of chemokines and their receptors interaction, which are essential for recruitment of selective lymphocyte subsets during inflammation, in the pathogenesis of idiopathic nonspecific interstitial pneumonia (NSIP ...
Ohtsuki, Yuji, Yoshinouchi, Takeo, Shigeki Sato, Shimizu, Shigeki, Shigeki Shimizu, Jiro Fujita, Eimoto, Tadaaki, Tadaaki Eimoto, Naniwa, Taio, Sato, Shigeki, Takeo Yoshinouchi, Yuji Ohtsuki, Fujita, Jiro, Taio Naniwa, Ueda, Ryuzo, Ryuzo Ueda   +15 more
core   +1 more source

Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome

Acta Dermato-Venereologica, 2019
Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lym­phomatoid papulosis and anaplastic large cell ...
Yuki Shono, Hiraku Suga, Hiroaki Kamijo, Hikari Fujii, Tomonori Oka, Tomomitsu Miyagaki, Naomi Shishido-Takahashi, Makoto Sugaya, Shinichi Sato   +8 more
doaj   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis

Biomolecules
Chemokines are cytokines with chemoattractant capacities that exert their physiological functions through the binding of chemokine receptors. Thus, chemokine and receptor complexes exert important roles in regulating development and homeostasis during ...
Zhi-Shuai Hou, Hong-Kui Zhao, Pedro Perdiguero, Meng-Qun Liu, Kai-Wen Xiang, Chu Zeng, Zhao Li, Xiao-Dong Yang, Qian Yang, Yuan-Ru Xin, Ji-Fang Li, Carolina Tafalla, Hai-Shen Wen   +12 more
doaj   +1 more source

Selective loss of chemokine receptor expression on leukocytes after cell isolation.

PLoS ONE, 2012
Chemokine receptors are distinctively exposed on cells to characterize their migration pattern. However, little is known about factors that may regulate their expression. To determine the optimal conditions for an accurate analysis of chemokine receptors,
Juan C Nieto, Elisabet Cantó, Carlos Zamora, M Angels Ortiz, Cándido Juárez, Silvia Vidal   +5 more
doaj   +1 more source

Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells

BMC Cancer, 2022
Background The chemokines, CXCL12 and CXCL11, are upregulated in tumors from many organs and control their progression. CXCL12 and CXCL11 affect tumor cell functions by either binding their prime receptors, CXCR4 and CXCR3, respectively, and/or CXCR7 as ...
Christian Koch, Nina Charlotte Fischer, Malte Puchert, Jürgen Engele   +3 more
doaj   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source