Results 41 to 50 of about 22,074 (250)
Mediators of Inflammation, 2015 Chemokine receptors play a role in leukocyte recruitment, activation, and maintaining effector functions and regulate adaptive immune response and angiogenesis. The study aimed at flow cytometric analysis of T cell subsets with selected surface chemokine
Maria Szczepańska +9 more
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BMC Neurology, 2010 Background The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors between the pathogenesis of ...
Nomura Fumio +5 more
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Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs [PDF]
International Journal of Cancer, 2009 AbstractMetastasis continues to be the leading cause of mortality for patients with cancer. Several years ago, it became clear that chemokines and their receptors could control the tumor progress. CXCR3 has now been identified in many cancers including osteosarcoma and CXCR3 ligands were expressed by lungs that are the primary sites to which this tumor
Emmanuelle, Pradelli +12 more
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Designing small molecule CXCR3 antagonists. [PDF]
, 2016 INTRODUCTION: By virtue of its specificity for chemokines induced in Th1-associated pathologies, CXCR3 has attracted considerable attention as a target for therapeutic intervention.
Pease, JE
core +1 more source
Frontiers in Immunology, 2020 In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However,
Abdul Wahid Ansari +14 more
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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis
Frontiers in Pharmacology, 2021 Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS).
Laetitia Pouzol +6 more
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The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 [PDF]
Proceedings of the National Academy of Sciences, 1998 We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine,
H, Soto +7 more
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The Role of Chemokine Receptor CXCR3 and Its Ligands in Renal Cell Carcinoma [PDF]
International Journal of Molecular Sciences, 2020 The major invasive subtype of kidney cancer is renal cell carcinoma (RCC). The essential components of cancer development are chronic inflammation and neoangiogenesis. It has been suggested that the chemokine ligand 9, -10, –11 (CXCL9–11) and chemokine receptor 3 (CXCR3) chemokines receptor expressed on monocytes, T and NK cells may be involved in the ...
Monika Gudowska-Sawczuk +2 more
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Frontiers in Immunology, 2022 Respiratory viral infections with SARS-CoV-2 and influenza viruses commonly induce a strong infiltration of immune cells into the human lung, with potential detrimental effects on the integrity of the lung tissue. Despite comprising the largest fractions
Demi Brownlie +15 more
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, 2012 The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells.
O'Boyle, Graeme +10 more
core +1 more source