Results 31 to 40 of about 22,074 (250)

Optic neuritis: chemokine receptor CXCR3 and its ligands [PDF]

British Journal of Ophthalmology, 2004
To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (
Sørensen, Torben Lykke, Roed, H, Sellebjerg, F   +2 more
openaire   +3 more sources

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3 [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSEThe chemokine receptor CXCR3 is a GPCR found predominantly on activated T cells. CXCR3 is activated by three endogenous peptides; CXCL9, CXCL10 and CXCL11. Recently, a small‐molecule agonist, VUF10661, has been reported in the literature and synthesized in our laboratory.
Scholten, D.J., Canals, M., Wijtmans, M., de Munnik, S.M., Nguyen, D, Verzijl, D., de Esch, I.J.P., Vischer, H.F., Smit, M.J., Leurs, R.   +9 more
openaire   +3 more sources

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG. [PDF]

, 2011
Subsets of NK cells can have distinct functions. Here, we report that >25% of human peripheral blood NK cells express HLA-DR after culture with IL-2.
Emma L. Wise, Riley, Eleanor M, Pease, James E, Horowitz, Amir, Evans, J Henry, Eleanor M. Riley, Riley, Eleanor M., James E. Pease, Wise, Emma L., Pease, James E., Davis, Daniel M., Wise, Emma L, Davis, Daniel M, J. Henry Evans, Mehrabi, Maryam, Maryam Mehrabi, Daniel M. Davis, Amir Horowitz, Evans, J. Henry   +18 more
core   +1 more source

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2010
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis.
Denise Silveira-Lemos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Adriano Luiz Souza-Soares, Pollyanna Castro-Silva, Matheus Fernandes Costa-Silva, Pedro Henrique Gazzinelli Guimarães, Helena Barbosa Ferraz, Lúcia Alves Oliveira-Fraga, Mauro Martins Teixeira, Rodrigo Corrêa-Oliveira   +10 more
doaj   +1 more source

Ovarian hormones and high-fat diet duration distinctively modulate hypothalamic chemokine profile. [PDF]

J Neuroendocrinol
Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Augusto AGB, Dos Santos GA, Cavalheiro IVS, Mantovan VS, Bergantini LS, Marin NP, Dos Santos Alves E, Velloso LA, Mendes NF.   +8 more
europepmc   +2 more sources

CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes [PDF]

, 2016
Many studies have suggested that CXCR3, CXCR5, CXCR6 and CXCR7 chemokine receptors are determinant in type 1 diabetes (T1D), expecially in autoimmunity and β-cell destruction.
Fallahi, P., Corrado, A., Di Domenicantonio, A., FRENZILLI, GIADA, ANTONELLI, ALESSANDRO, Ferrari, S. M.   +5 more
core   +1 more source

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light [PDF]

Beilstein Journal of Organic Chemistry, 2019
We report a detailed structure-activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A total of 31 photoswitchable azobenzene ligands was prepared through various synthetic strategies and multistep syntheses.
Xavier Gómez-Santacana, Sabrina M de Munnik, Tamara A M Mocking, Niels J Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J P de Esch, Henry F Vischer, Maikel Wijtmans, Rob Leurs   +9 more
openaire   +4 more sources

Chemokine Receptors and Phagocyte Biology in Zebrafish. [PDF]

, 2020
Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Sommer, F., Torraca, Vincenzo, Sommer, Frida, Meijer, Annemarie H, Meijer, Annemarie H., Torraca, V., Meijer, A.H.   +6 more
core   +1 more source