Results 11 to 20 of about 22,074 (250)

The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells

Haematologica, 2007
Background and Objectives Chemokine receptors are involved in tumor progression and several of these receptors, including CXCR3, are expressed by chronic lymphocytic leukemia (CLL) B cells.
Esther Ocaña, Luis Delgado-Pérez, Antonio Campos-Caro, Juan Muñóz, Antonio Paz, Rafael Franco, José A. Brieva   +6 more
doaj   +3 more sources

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system

Nature Communications
Chemokine receptors are critically involved in multiple physiological and pathophysiological processes related to immune response mechanisms. Most chemokine receptors are prototypical GPCRs although some also exhibit naturally-encoded signaling-bias ...
Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Annu Dalal, Sudha Mishra, Divyanshu Tiwari, Hiroaki Akasaka, Takaaki A. Kobayashi, Nabarun Roy, Nashrah Zaidi, Yuzuru Itoh, Rob Leurs, Ramanuj Banerjee, Wataru Shihoya, Osamu Nureki, Arun K. Shukla   +16 more
doaj   +2 more sources

Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells [PDF]

Journal of Biological Chemistry, 2001
Chemokines are secreted into the tumor microenvironment by tumor-infiltrating inflammatory cells as well as by tumor cells. Chemokine receptors mediate agonist-dependent cell responses, including migration and activation of several signaling pathways.
Robledo, M.M., Bartolome, R.A., Longo, N., Rodriguez-Frade, J.M., Mellado, M., Longo, I., Muijen, G.N.P. van, Sanchez-Mateos, P., Teixido, J.   +8 more
openaire   +6 more sources

Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes [PDF]

British Journal of Pharmacology, 2013
Background and PurposeThe C‐X‐C chemokine receptors 3 (CXCR3) and C‐X‐C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross‐inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form
Watts, A. O, van Lipzig, M. M. H, Jaeger, W. C, Seeber, R. M, van Zwam, M, VINET, JONATHAN, van der Lee, M. M. C, Siderius, M, Zaman, G. J. R, Boddeke, H. W. G. M, Smit, M. J, Pfleger, K. D. G, Leurs, R, Vischer, H. F.   +13 more
openaire   +4 more sources

Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma

Cell Death Discovery
The chemokine receptor CXCR3 is traditionally recognized for its role in immune cell trafficking. However, emerging evidence suggests that its functions may extend beyond the immune system, particularly in cancer, where its roles remain to be elucidated.
Travis Yui Hei Chan, Bo Chen, Wanjun Tang, Henry Hei Chan, Yogesh K. H. Wong, Ethan C. L. Wong, Junbo Liao, Anson Cho-Kiu Ng, Jenny Sum Yee Wong, Gilberto Ka-Kit Leung, Karrie M. Kiang   +10 more
doaj   +2 more sources

Pro-tumoural CXCL10/CXCR3-A autocrine loop in invasive mucinous lung adenocarcinoma

ERJ Open Research, 2017
Invasive mucinous adenocarcinoma (IMA) is a mucinous variant of lepidic predominant lung adenocarcinoma (LPA) and associated with a worse prognosis.
Michaël Duruisseaux, Nathalie Rabbe, Martine Antoine, Thibault Vieira, Virginie Poulot, Jacques Cadranel, Marie Wislez   +6 more
doaj   +2 more sources

ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR

Инфекция и иммунитет, 2014
. In case of hepatitis C the adequate adaptive immune response depends on T-helper lymphocyte subsets and recruiting specific T cells in the site of infection.
D. S. Elezov, I. V. Kudryavtsev, N. A. Arsentieva, A. V. Semenov, E. V. Esaulenko, V. V. Basina, Areg A. Totolian   +6 more
doaj   +2 more sources

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6. [PDF]

PLoS ONE, 2017
Chemokines and their receptors are pivotal for the trafficking of leukocytes during immune responses, and host defense. However, immune cell migration also contributes to a wide variety of autoimmune and chronic inflammatory diseases. Compelling evidence
Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl J H Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay   +7 more
doaj   +2 more sources

ROLE OF CXCR3 CHEMOKINE RECEPTOR AND ITS LIGANDS IN CERTAIN DISEASES

Медицинская иммунология, 2019
Chemokines are a special family of cytokines whose main function is to control cell migration; they are key players in the innate and adaptive immune responses.
N. A. Arsentieva, A. V. Semenov, D. A. Zhebrun, E. V. Vasilyeva, Areg A. Totolian   +4 more
doaj   +3 more sources

CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection. [PDF]

PLoS Pathogens, 2013
Chemokines and their receptors play a critical role in orchestrating immunity to microbial pathogens, including the orally acquired Th1-inducing protozoan parasite Toxoplasma gondii.
Sara B Cohen, Kirk J Maurer, Charlotte E Egan, Steve Oghumu, Abhay R Satoskar, Eric Y Denkers   +5 more
doaj   +2 more sources