Results 1 to 10 of about 20,978 (166)
Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis [PDF]
Arthritis Research & Therapy, 2018 Background The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients ...
Florian Weigold +16 more
doaj +2 more sources
The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer
Frontiers in Medicine, 2018 Chemokines and their receptors play an important role in the recruitment, activation and differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9, CXCL10, and CXCL11 are key immune chemoattractants during interferon-induced ...
Zhen Zeng +2 more
exaly +3 more sources
CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond
Frontiers in Immunology, 2020 CXCR3 is a chemokine receptor with three ligands; CXCL9, CXCL10, and CXCL11. CXCL11 binds CXCR3 with a higher affinity than the other ligands leading to receptor internalization.
Nathan Karin, Karin Nathan
exaly +3 more sources
The prognostic significance of chemokine receptor CXCR3 expression in colorectal carcinoma
Biomedicine and Pharmacotherapy, 2012 The expression of chemokine receptor CXCR3 has been associated with tumor dissemination and poor prognosis in breast cancer patients. However, it is still unclear whether CXCR3 can be used as an independent molecular marker for predicting the prognosis of colonrectal carcinoma (CRC) patients.
Zhenqian Wu +2 more
exaly +3 more sources
The role of CXCR3 and its ligands in cancer
Frontiers in Oncology, 2022 Chemokines are a class of small cytokines or signaling proteins that are secreted by cells. Owing to their ability to induce directional chemotaxis of nearby responding cells, they are called chemotactic cytokines. Chemokines and chemokine receptors have
Xiaoming Wang +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Chemokines form a sophisticated communication network wherein they maneuver the spatiotemporal migration of immune cells across a system. These chemical messengers are recognized by chemokine receptors, which can trigger a cascade of reactions upon ...
Devi Satarkar +2 more
doaj +1 more source
Regulation of pulmonary fibrosis by chemokine receptor CXCR3 [PDF]
Journal of Clinical Investigation, 2004 CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-gamma-inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on activated immune cells and proliferating endothelial cells. The role of CXCR3 in fibroproliferation has not been investigated. We examined the role of CXCR3 in pulmonary injury and repair in vivo.
Dianhua, Jiang +11 more
openaire +2 more sources
Chemokine receptor CXCR3 promotes growth of glioma [PDF]
Carcinogenesis, 2010 Human glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of GBM indicates a need to identify new therapeutic targets. In this study, we examined the role of CXCR3 in glioma progression using the GL261 murine model of malignant glioma.
Che, Liu +8 more
openaire +2 more sources
CXCR3 chemokine receptor ligands in sarcoidosis
Medical Immunology (Russia), 2021 Sarcoidosis is a polysystemic inflammatory disease of unknown etiology, morphologically related to the group of granulomatosis, with heterogeneous clinical manifestations and outcomes. Immune cells, in particular T helper cells, are attracted to lung tissue and/or other organs by chemokine gradients and play an important role in the granuloma formation.
N. M. Lazareva +7 more
openaire +3 more sources
Structure and function of the murine chemokine receptor CXCR3 [PDF]
European Journal of Immunology, 1999 The gene encoding the murine homologue of human CXCR3 exists in a single copy consisting of two exons with an intron interrupting the coding sequence between nucleotides 10 and 11. The deduced amino acid sequence is 86% identical to the predicted human sequence.
B, Lu +7 more
openaire +2 more sources