Results 81 to 90 of about 22,074 (250)

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation [PDF]

Science Signaling, 2018
Small-molecule biased agonists of a chemokine receptor elicit distinct physiological outcomes.
Jeffrey S. Smith, Lowell T. Nicholson, Jutamas Suwanpradid, Rachel A. Glenn, Nicole M. Knape, Priya Alagesan, Jaimee N. Gundry, Thomas S. Wehrman, Amber Reck Atwater, Michael D. Gunn, Amanda S. MacLeod, Sudarshan Rajagopal   +11 more
openaire   +2 more sources

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Autocrine Regulation of Re-Epithelialization After Wounding by Chemokine Receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3

, 2012
This study identifies chemokine receptors involved in an autocrine regulation of re-epithelialization after skin tissue damage. We determined which receptors, from a panel of 13, are expressed in healthy human epidermis and which monospecific chemokine ...
Waaijman, Taco, Sampat-Sardjoepersad, S.C., Gibbs, Susan, Kim L. Kroeze, Susan Gibbs, Shakun C. Sampat-Sardjoepersad, Waaijman, T., Rik J. Scheper, Boink, Mireille A., Kroeze, Kim L., Mireille A. Boink, Boink, M.A., Taco Waaijman, Scheper, Rik J., Scheper, R.J., Kroeze, K.L., Gibbs, S., Sampat-Sardjoepersad, Shakun C.   +17 more
core   +1 more source

Temporary CXCR3 and CCR5 Antagonism Following Vaccination Enhances Memory CD8 T Cell Immune Responses

Molecular Medicine, 2016
Although current vaccination strategies have been successful at preventing a variety of human diseases, attempts at vaccinating against some pathogens such as AIDS and tuberculosis (TB) have been more problematic, largely because abnormally high numbers ...
Rui Li, Nan Zhang, Miaomiao Tian, Zihan Ran, Mingjun Zhu, Haiyan Zhu, Fangting Han, Juan Yin, Jiang Zhong   +8 more
doaj   +1 more source

Expression of the Chemokine Receptors CXCR3, CXCR4, CXCR7 and Their Ligands in Rhabdomyosarcoma

Pathology & Oncology Research, 2015
Rhabdomyosarcomas (RMS) are soft tissue malignant tumors of childhood and adolescents. The mechanisms underlying their aggressiveness are still poorly understood. Chemokines are chemotactic proteins involved in pathological processes that have been intensely studied in several types of cancers because of their influence in migration, angiogenesis, or ...
Teresa, San-Miguel, Sandra, Pinto, Lara, Navarro, Robert C, Callaghan, Carlos, Monteagudo, Concha, López-Ginés, Miguel, Cerdá-Nicolás, Rosario, Gil-Benso   +7 more
openaire   +2 more sources

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Nickel-responding T cells are CD4+ CLA+ CB45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10

, 2004
Background: Whereas T lymphocytes are widely accepted as effector cells determining the pathogenesis of allergic contact dermatitis, contradictory results have been found regarding the roles of different T-cell subsets.
Bruynzeel, D. P., Scheper, R. J., Moed, H., Stoof, T. J., Boorsma, D. M., Von Blomberg, B. M.E., Gibbs, S., Rustemeyer, T.   +7 more
core   +1 more source

Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice [PDF]

Neuroscience Bulletin, 2017
Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis (ACD). CXCR3 in the spinal cord also contributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear.
Peng-Bo, Jing, De-Li, Cao, Si-Si, Li, Meixuan, Zhu, Xue-Qiang, Bai, Xiao-Bo, Wu, Yong-Jing, Gao   +6 more
openaire   +2 more sources

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism.

, 2009
International audienceLiver and lung metastases are the predominant cause of colorectal cancer (CRC)-related mortality. Recent research has indicated that CXCR3/chemokines interactions that orchestrate haematopoetic cell movement are implicated in the ...
V Martini, D Birnbaum, Collins, T. L., Scoazec, J. Y., Abello, J., Cambien, B., H Bziouech, Millet, Marc-Alban, T Al Saati, H Schmid-Antomarchi, Schmid-Antomarchi, H., Karimdjee, B. F., J Abello, Medina, J. C., Schmid-Alliana, A., J Y Scoazec, J C Medina, Martini, V., M A Millet, A Schmid-Alliana, Richard-Fiardo, P., M G Johnson, Sullivan, T. J., Johnson, M. G., T J Sullivan, Barthel, R., Saati, T Al, P Richard-Fiardo, R Barthel, Birnbaum, D., B F Karimdjee, T L Collins, B Cambien, Bziouech, H.   +33 more
core   +1 more source